Title:
COMPOUND HAVING ANTISPORULANT ACTIVITY AND PHARMACEUTICAL COMPOSITION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/147123
Kind Code:
A1
Abstract:
The present invention provides a compound having antisporulant activity and a pharmaceutical composition thereof, and specifically provides a compound represented by formula (I), or a salt thereof, or a stereoisomer thereof. The compound can effectively inhibit the germination of clostridium difficile spores, has significant antibacterial activity, and has a very good application prospect in the preparation of a medication for preventing and/or treating a clostridium difficile infectious disease, recurrence of the clostridium difficile infectious disease, or the complication of the clostridium difficile infectious disease.
Inventors:
GUANG BING (CN)
YANG TAI (CN)
DONG RENHAN (CN)
LIU JIN (CN)
XIE JIAN (CN)
QIN CHUANJUN (CN)
HUANG SHENG (CN)
PENG XIANGYANG (CN)
XU QING (CN)
LAI YONGXIN (CN)
ZHAN WEI (CN)
PENG JIAN (CN)
WANG XIAOHUI (CN)
YANG TAI (CN)
DONG RENHAN (CN)
LIU JIN (CN)
XIE JIAN (CN)
QIN CHUANJUN (CN)
HUANG SHENG (CN)
PENG XIANGYANG (CN)
XU QING (CN)
LAI YONGXIN (CN)
ZHAN WEI (CN)
PENG JIAN (CN)
WANG XIAOHUI (CN)
Application Number:
PCT/CN2020/074462
Publication Date:
July 29, 2021
Filing Date:
February 07, 2020
Export Citation:
Assignee:
CHENGDU BIOBEL COMPANY LTD (CN)
International Classes:
A61K31/58; C07J43/00; A61P1/00; A61P31/04
Foreign References:
| CN107108687A | 2017-08-29 | |||
| US20140045808A1 | 2014-02-13 |
Other References:
SHARMA SHIV K., YIP CHRISTOPHER, ESPOSITO EMILIO XAVIER, SHARMA PRATEEK V., SIMON MATTHEW P., ABEL-SANTOS ERNESTO, FIRESTINE STEVE: "The Design, Synthesis, and Characterizations of Spore Germination Inhibitors Effective against an Epidemic Strain of Clostridium difficile", JOURNAL OF MEDICINAL CHEMISTRY, vol. 61, no. 15, 9 August 2018 (2018-08-09), pages 6759 - 6778, XP055830862, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.8b00632
STOLTZ KRISTEN L., ERICKSON RAYMOND, STALEY CHRISTOPHER, WEINGARDEN ALEXA R., ROMENS ERIN, STEER CLIFFORD J., KHORUTS ALEXANDER, S: "Synthesis and Biological Evaluation of Bile Acid Analogues Inhibitory to Clostridium difficile Spore Germination", JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, no. 8, 27 April 2017 (2017-04-27), pages 3451 - 3471, XP055830861, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.7b00295
STOLTZ KRISTEN L., ERICKSON RAYMOND, STALEY CHRISTOPHER, WEINGARDEN ALEXA R., ROMENS ERIN, STEER CLIFFORD J., KHORUTS ALEXANDER, S: "Synthesis and Biological Evaluation of Bile Acid Analogues Inhibitory to Clostridium difficile Spore Germination", JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, no. 8, 27 April 2017 (2017-04-27), pages 3451 - 3471, XP055830861, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.7b00295
Attorney, Agent or Firm:
GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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