Title:
COMPOUND HAVING BTK KINASE DEGRADING ACTIVITY, AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREFOR
Document Type and Number:
WIPO Patent Application WO/2022/007824
Kind Code:
A1
Abstract:
A compound as shown in general formula (I) or stereoisomers, deuterated compounds, solvates, prodrugs, metabolites, pharmaceutically acceptable salts or co-crystals thereof, and intermediates thereof, a preparation method therefor, and a use thereof for treating BTK-related diseases, such as cancer or autoimmune diseases. B-L-K (I)
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Inventors:
ZHANG CHEN (CN)
LIAO YUTING (CN)
WANG JIANMIN (CN)
CHENG XINFAN (CN)
CHEN XIAOGANG (CN)
ZOU SIJIA (CN)
YUAN SHUAI (CN)
YE FEI (CN)
TANG PINGMING (CN)
ZHU GUOZHI (CN)
HUANG ZHENGGANG (CN)
WU SHOUTAO (CN)
LI YAO (CN)
NI JIA (CN)
YAN PANGKE (CN)
LIAO YUTING (CN)
WANG JIANMIN (CN)
CHENG XINFAN (CN)
CHEN XIAOGANG (CN)
ZOU SIJIA (CN)
YUAN SHUAI (CN)
YE FEI (CN)
TANG PINGMING (CN)
ZHU GUOZHI (CN)
HUANG ZHENGGANG (CN)
WU SHOUTAO (CN)
LI YAO (CN)
NI JIA (CN)
YAN PANGKE (CN)
Application Number:
PCT/CN2021/104905
Publication Date:
January 13, 2022
Filing Date:
July 07, 2021
Export Citation:
Assignee:
SICHUAN HAISCO PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D487/04; A61K31/395; A61P19/02; A61P25/00; A61P29/00; A61P35/00; A61P37/06; C07D403/00
Domestic Patent References:
| WO2020239103A1 | 2020-12-03 | |||
| WO2019127008A1 | 2019-07-04 | |||
| WO2020252397A1 | 2020-12-17 | |||
| WO2021018018A1 | 2021-02-04 | |||
| WO2017197056A1 | 2017-11-16 | |||
| WO2020239103A1 | 2020-12-03 | |||
| WO2018033853A2 | 2018-02-22 | |||
| WO2018089355A1 | 2018-05-17 |
Foreign References:
| CN110724143A | 2020-01-24 | |||
| CN110845500A | 2020-02-28 | |||
| CN112010858A | 2020-12-01 | |||
| CN110627796A | 2019-12-31 |
Other References:
J. MED. CHEM., vol. 58, 2015, pages 9625 - 9638
Y. SUN, X. ZHAO, N. DING, H. GAO, Y. WU, Y. YANG, M. ZHAO, J. HWANG, Y. SONG, W. LIU, Y. RAO, CELL RES, vol. 28, 2018, pages 779 - 781
ORG. BIOMOL. CHEM., vol. 11, 2013, pages 4757 - 4763
Y. SUN, X. ZHAO, N. DING, H. GAO, Y. WU, Y. YANG, M. ZHAO, J. HWANG, Y. SONG, W. LIU, Y. RAO, CELL RES, vol. 28, 2018, pages 779 - 781
ORG. BIOMOL. CHEM., vol. 11, 2013, pages 4757 - 4763
Attorney, Agent or Firm:
BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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