Title:
COMPOUND HAVING EP2 AGONISTIC ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2017/014315
Kind Code:
A1
Abstract:
Provided is an EP2 agonist having a high safety. A compound represented by general formula (I) (wherein each symbol is as defined in the description), a salt thereof, an N-oxide derivative thereof, a solvate of the same or a prodrug of the same has an EP2 agonistic activity and a high safety and, therefore, is useful as a medicine, in particular a therapeutic agent for diseases associated with EP2 receptor such as immune diseases, allergic diseases, nerve cell death, dysmenorrhea, premature delivery, abortion, baldness, eye diseases, erectile dysfunction, arthritis, pulmonary damage, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive respiratory diseases, bone diseases and cartilage damage.
Inventors:
OGAWA SEIJI (JP)
WATANABE TOSHIHIDE (JP)
SUGIMOTO ISAMU (JP)
TANI KOUSUKE (JP)
MORIYUKI KAZUMI (JP)
GOTO YOSHIKAZU (JP)
YAMANE SHINSAKU (JP)
WATANABE TOSHIHIDE (JP)
SUGIMOTO ISAMU (JP)
TANI KOUSUKE (JP)
MORIYUKI KAZUMI (JP)
GOTO YOSHIKAZU (JP)
YAMANE SHINSAKU (JP)
Application Number:
PCT/JP2016/071611
Publication Date:
January 26, 2017
Filing Date:
July 22, 2016
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
International Classes:
C07D407/04; A61K31/352; A61K31/381; A61K31/427; A61K31/428; A61P1/04; A61P1/16; A61P7/00; A61P9/00; A61P11/00; A61P13/12; A61P15/00; A61P15/06; A61P15/10; A61P17/02; A61P19/00; A61P19/02; A61P25/00; A61P27/02; A61P29/00; A61P31/04; A61P37/02; A61P37/08; A61P43/00; C07D409/04; C07D417/04; C07D417/14
Domestic Patent References:
| WO2011013651A1 | 2011-02-03 | |||
| WO1999033794A1 | 1999-07-08 | |||
| WO2009006370A1 | 2009-01-08 | |||
| WO2015129782A1 | 2015-09-03 |
Foreign References:
| US4281113A | 1981-07-28 | |||
| US4740523A | 1988-04-26 |
Other References:
OGAWA S. ET AL.: "Discovery of G protein-biased EP 2 receptor agonists", ACS MEDICINAL CHEMISTRY LETTERS, vol. 7, pages 306 - 11, XP055348406, ISSN: 1948-5875
OGAWA S. ET AL.: "Structural optimization and structure-functional selectivity relationship studies of G protein-biased EP 2 receptor agonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 26, 31 March 2016 (2016-03-31), pages 2446 - 9, XP029659119, ISSN: 0960-894X
See also references of EP 3327018A4
OGAWA S. ET AL.: "Structural optimization and structure-functional selectivity relationship studies of G protein-biased EP 2 receptor agonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 26, 31 March 2016 (2016-03-31), pages 2446 - 9, XP029659119, ISSN: 0960-894X
See also references of EP 3327018A4
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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