Title:
COMPOUND HAVING HIGH AFFINITY FOR CD22 MOLECULE AND CAPABLE OF ENHANCING PROLIFERATION OF B CELLS
Document Type and Number:
WIPO Patent Application WO/2011/013398
Kind Code:
A1
Abstract:
Disclosed is a compound which has a high affinity for a CD22 molecule in a B cell and can enhance an immune response to thereby exhibit activities including an activity of enhancing the proliferation of B cells and an activity of increasing the resistance against infectious diseases such as virus-mediated diseases. The compound is a sialic acid derivative represented by chemical formula (1) (wherein R1 and R2 independently represent an aromatic hydrocarbon group which may have a substituent) or a prodrug thereof, or a pharmaceutically acceptable salt or hydrate of the derivative or prodrug.
Inventors:
TSUBATA TAKESHI (JP)
KISO MAKOTO (JP)
ISHIDA HIDEHARU (JP)
ABDU-ALLAH HAJJAJ HASSAN MOHAMED (JP)
KISO MAKOTO (JP)
ISHIDA HIDEHARU (JP)
ABDU-ALLAH HAJJAJ HASSAN MOHAMED (JP)
Application Number:
PCT/JP2010/054406
Publication Date:
February 03, 2011
Filing Date:
March 16, 2010
Export Citation:
Assignee:
UNIV GIFU (JP)
JAPAN SCIENCE & TECH AGENCY (JP)
TSUBATA TAKESHI (JP)
KISO MAKOTO (JP)
ISHIDA HIDEHARU (JP)
ABDU-ALLAH HAJJAJ HASSAN MOHAMED (JP)
JAPAN SCIENCE & TECH AGENCY (JP)
TSUBATA TAKESHI (JP)
KISO MAKOTO (JP)
ISHIDA HIDEHARU (JP)
ABDU-ALLAH HAJJAJ HASSAN MOHAMED (JP)
International Classes:
C07H7/027; A61K31/7012; A61P37/04
Other References:
ABDU-ALLAH, H.H.M. ET AL.: "Exploring structure- affinity relationships of CD22- inhibitors", CREST KOKUSAI SYMPOSIUM 'KAKUTOKU MEN'EKI TO TOSA SEIBUTSUGAKU' YOKOSHU, CHIBA- KEN KISARAZU-SHI, pages 22
ABDU-ALLAH, H.H.M. ET AL.: "Design, synthesis, and structure-affinity relationships of novel series of sialosides as CD22-specific inhibitors", J. MED. CHEM., vol. 51, 2008, pages 6665 - 6681
ABDU-ALLAH, H.H.M. ET AL.: "Synthesis ob biotinylated sialoside to probe CD22-ligand interactions", TETRAHEDRON LETT., vol. 50, 22 May 2009 (2009-05-22), pages 4488 - 4491, XP026193551, DOI: doi:10.1016/j.tetlet.2009.05.044
COLLINS, B.E. ET AL.: "High-affinity ligand probes of CD22 overcome the threshold set by cis ligands to allow for binding, endocytosis, and killing of B cells", J. IMMUNOLOGY, vol. 177, 2006, pages 2994 - 3003, XP003013261
KELM, S. ET AL.: "The ligand-binding domain of CD22 is needed for inhibition of the B cell receptor signal, as demonstrated by a novel human CD22-specific inhibitor compound", J. EXP. MED., vol. 195, 2002, pages 1207 - 1213, XP055111898, DOI: doi:10.1084/jem.20011783
ROSSENBERG, S.M.W. ET AL.: "A structure-function study of ligand recognition by CD22beta", J. BIOL. CHEM., vol. 276, 2001, pages 12967 - 12973, XP055205982, DOI: doi:10.1074/jbc.M009276200
ABDU-ALLAH, H.H.M. ET AL.: "Design, synthesis, and structure-affinity relationships of novel series of sialosides as CD22-specific inhibitors", J. MED. CHEM., vol. 51, 2008, pages 6665 - 6681
ABDU-ALLAH, H.H.M. ET AL.: "Synthesis ob biotinylated sialoside to probe CD22-ligand interactions", TETRAHEDRON LETT., vol. 50, 22 May 2009 (2009-05-22), pages 4488 - 4491, XP026193551, DOI: doi:10.1016/j.tetlet.2009.05.044
COLLINS, B.E. ET AL.: "High-affinity ligand probes of CD22 overcome the threshold set by cis ligands to allow for binding, endocytosis, and killing of B cells", J. IMMUNOLOGY, vol. 177, 2006, pages 2994 - 3003, XP003013261
KELM, S. ET AL.: "The ligand-binding domain of CD22 is needed for inhibition of the B cell receptor signal, as demonstrated by a novel human CD22-specific inhibitor compound", J. EXP. MED., vol. 195, 2002, pages 1207 - 1213, XP055111898, DOI: doi:10.1084/jem.20011783
ROSSENBERG, S.M.W. ET AL.: "A structure-function study of ligand recognition by CD22beta", J. BIOL. CHEM., vol. 276, 2001, pages 12967 - 12973, XP055205982, DOI: doi:10.1074/jbc.M009276200
Attorney, Agent or Firm:
MAYAMA, Setsuko et al. (JP)
Setsuko Mayama (JP)
Setsuko Mayama (JP)
Download PDF: