Title:
COMPOUND HAVING LYSOPHOSPHATIDIC ACID RECEPTOR AGONISTIC ACTIVITY AND PHARMACEUTICAL USE OF SAID COMPOUND
Document Type and Number:
WIPO Patent Application WO/2021/107125
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a pharmaceutical having, as an active ingredient, a compound having agonistic activity on LPA3. As a result of having performed thoroughgoing studies, the inventors perfected the present invention upon discovering, as substances capable of overcoming the aforestated problem, compounds represented by general formula (IY) (all the symbols represent the same meanings as those described in the specification) having agonistic activity on LPA3. Due to having agonistic activity on LPA3, the compounds represented by general formula (IY) of the present invention can be used as an active ingredient of an agent for the prevention and/or treatment of essential thrombocythemia or reactive thrombocytosis.
Inventors:
IWAKI YUZO (JP)
ENDO TOSHIMITSU (JP)
KUSUMI KENSUKE (JP)
ENDO TOSHIMITSU (JP)
KUSUMI KENSUKE (JP)
Application Number:
PCT/JP2020/044318
Publication Date:
June 03, 2021
Filing Date:
November 27, 2020
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
International Classes:
A61P7/00; A61K31/401; A61K31/403; A61K31/4045; A61K31/407; A61K31/429; A61K31/437; A61P43/00; C07D207/34; C07D209/42; C07D209/52; C07D409/04; C07D409/12; C07D471/04; C07D495/04; C07D513/04
Domestic Patent References:
| WO2014172705A1 | 2014-10-23 | |||
| WO2008130970A1 | 2008-10-30 | |||
| WO2007112322A2 | 2007-10-04 | |||
| WO2006007448A2 | 2006-01-19 |
Foreign References:
| JP2014508111A | 2014-04-03 | |||
| JP2019518766A | 2019-07-04 | |||
| JP2013506694A | 2013-02-28 | |||
| JP2014525932A | 2014-10-02 | |||
| US2868691A | 1959-01-13 | |||
| US3095355A | 1963-06-25 |
Other References:
DATABASE CAS [online] 2011, XP055833100, retrieved from STN Database accession no. 1287091-90-0
PROGRAM AND PROCEEDINGS OF THE 93RD ANNUAL MEETING OF THE JAPAN BIOCHEMICAL SOCIETY
HIROKAWA SHOTEN: "Development of Drug", MOLECULAR DESIGN, vol. 7, 1990, pages 163 - 198
RICHARD C. LAROCK: "Comprehensive Organic Transformations: A Guide to Functional Group Preparations", 1999, JOHN WILEY & SONS INC
P. G. M. WUTST. W. GREENE: "Green's Protective Groups in Organic Synthesis", 2007, WILEY
"Encyclopedia of Pharmaceutical Additives", 2000, YAKUJI NIPPO, LIMITED
See also references of EP 4066895A1
PROGRAM AND PROCEEDINGS OF THE 93RD ANNUAL MEETING OF THE JAPAN BIOCHEMICAL SOCIETY
HIROKAWA SHOTEN: "Development of Drug", MOLECULAR DESIGN, vol. 7, 1990, pages 163 - 198
RICHARD C. LAROCK: "Comprehensive Organic Transformations: A Guide to Functional Group Preparations", 1999, JOHN WILEY & SONS INC
P. G. M. WUTST. W. GREENE: "Green's Protective Groups in Organic Synthesis", 2007, WILEY
"Encyclopedia of Pharmaceutical Additives", 2000, YAKUJI NIPPO, LIMITED
See also references of EP 4066895A1
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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