Title:
COMPOUND HAVING SUBSTANCE THAT HAS AFFINITY FOR SOLUBLE PROTEIN, CLEAVABLE MOIETY, AND REACTIVE GROUP, OR SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/199337
Kind Code:
A1
Abstract:
The present invention provides a technique that enables modification of a soluble protein, particularly regioselective modification of a soluble protein. More specifically, the present invention provides a compound having a substance that has affinity for a soluble protein, a cleavable moiety, and a reactive group, the compound being represented by formula (I): A-L-B-R [in the formula, A is a substance that has affinity for a soluble protein, L is a cleavable linker that is a divalent group containing a cleavable moiety, B is (a) a divalent group containing a bioorthogonal functional group or (b) a divalent group not containing a bioorthogonal functional group, and R is a group that is reactive to the soluble protein], or a salt thereof.
Inventors:
YAMADA KEI (JP)
MATSUDA YUTAKA (JP)
FUJII TOMOHIRO (JP)
SHIKIDA NATSUKI (JP)
YUJI REIKO (JP)
SHIMBO KAZUTAKA (JP)
ITO YUJI (JP)
MATSUDA YUTAKA (JP)
FUJII TOMOHIRO (JP)
SHIKIDA NATSUKI (JP)
YUJI REIKO (JP)
SHIMBO KAZUTAKA (JP)
ITO YUJI (JP)
Application Number:
PCT/JP2018/017345
Publication Date:
November 01, 2018
Filing Date:
April 27, 2018
Export Citation:
Assignee:
AJINOMOTO KK (JP)
International Classes:
C07K19/00; C07K16/00; C12N15/09
Domestic Patent References:
| WO2015191883A1 | 2015-12-17 | |||
| WO2016186206A1 | 2016-11-24 | |||
| WO2017191817A1 | 2017-11-09 | |||
| WO2017217347A1 | 2017-12-21 | |||
| WO2016186206A1 | 2016-11-24 | |||
| WO2013027796A1 | 2013-02-28 | |||
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| WO2005112919A2 | 2005-12-01 |
Foreign References:
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| US5824805A | 1998-10-20 |
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DESIMONE, J. M., JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 132, 2010, pages 17928
SCHOENMARKS, R. G., JOURNAL OF CONTROLLED RELEASE, vol. 95, 2004, pages 291
THOMPSON, D. H., JOURNAL OF CONTROLLED RELEASE, vol. 91, 2003, pages 187
SHARPLESS K. B. ET AL., ANGEW. CHEM. INT. ED., vol. 40, 2015, pages 2004
BERTOZZI C. R. ET AL., SCIENCE, vol. 291, 2001, pages 2357
BERTOZZI C. R. ET AL., NATURE CHEMICAL BIOLOGY, vol. 1, 2005, pages 13
G. J. L. BERNARDES ET AL., CHEM. REV., vol. 115, 2015, pages 2174
G. J. L. BERNARDES ET AL., CHEM. ASIAN. J., vol. 4, 2009, pages 630
B. G. DAVIES ET AL., NAT. COMMUN., vol. 5, 2014, pages 4740
A. WAGNER ET AL., BIOCONJUGATE. CHEM., vol. 25, 2014, pages 825
DUBOWCHIK ET AL., PHARM. THERAPEUTICS, vol. 83, 1999, pages 67 - 123
JAGATH R JUNUTULA ET AL., NATURE BIOTECHNOLOGY, vol. 26, no. 8, 2008, pages 925 - 932
SHIMIZU SHIGEOMI ET AL: "Development of radiopharmaceuticals using antibody site-specific modificaton method ", 1 February 2018 (2018-02-01), pages 12 - 15, XP055642377, Retrieved from the Internet
REICHERT JM ET AL., NAT BIOTECHNOL, vol. 23, 2005, pages 1137 - 46
KUBOTA T ET AL., CANCER SCI, vol. 100, 2009, pages 1566 - 72
JUNUTULA JR ET AL., NAT BIOTECHNOL, vol. 26, 2008, pages 925 - 32
SHEN BQ ET AL., NAT BIOTECHNOL, vol. 30, 2012, pages 184 - 9
HOFER T ET AL., BIOCHEMISTRY, vol. 48, 2009, pages 12047 - 57
LIU W ET AL., NAT METHODS, vol. 4, 2007, pages 239 - 44
S. T. LAUGHLIN ET AL., SCIENCE, vol. 320, 2008, pages 664
A. E. SPEERS ET AL., CHEMBIOCHEM, vol. 5, 2004, pages 41
Y. TAKAOKA ET AL., ANGEW. CHEM. INT. ED., vol. 52, 2013, pages 4088
FASSINA G ET AL., JOURNAL OF MOLECULAR RECOGNITION, vol. 6, 1996, pages 564 - 569
EHRLICH G. K ET AL., J. BIOCHEM. BIOPHYS. METHODS, vol. 49, 2001, pages 443 - 454
RUVO M ET AL., CHEMBIOCHEM, vol. 6, 2005, pages 1242 - 1253
KROOK M ET AL., JOURNAL OF IMMUNOLOGICAL METHODS, vol. 221, 1998, pages 151 - 157
JACOBS J. M. ET AL., BIO. TECHNIQUES, vol. 34, 2003, pages 132 - 141
CARBONELL R. G. ET AL., JOURNAL OF CHROMATOGRAPHY A, vol. 1216, 2009, pages 910 - 918
LUND L. N. ET AL., JOURNAL OF CHROMATOGRAPHY A, vol. 1225, 2012, pages 158 - 167
WARREN L. DELANO ET AL., SCIENCE, vol. 287, 2000, pages 1279 - 1283
BIOCHEMICAL ENGINEERING JOURNAL, vol. 79, 2013, pages 33 - 40
NOMURA Y ET AL., NUCLEIC ACIDS RES., vol. 38, no. 21, November 2010 (2010-11-01), pages 7822 - 9
MIYAKAWA S ET AL., RNA, vol. 14, no. 6, June 2008 (2008-06-01), pages 1154 - 63
STAROVASNIK, M. A. ET AL.: "Structural mimicry of a native protein by a minimized binding domain.", PROC. NATL. ACAD. SCI. USA., vol. 94, 1997, pages 10080 - 10085, XP055563260, DOI: 10.1073/pnas.94.19.10080
G. LERICHEL. CHISHOLMA. WAGNER, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 20, 2012, pages 571
DESIMONE, J. M., JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 132, 2010, pages 17928
SCHOENMARKS, R. G., JOURNAL OF CONTROLLED RELEASE, vol. 95, 2004, pages 291
THOMPSON, D. H., JOURNAL OF CONTROLLED RELEASE, vol. 91, 2003, pages 187
SHARPLESS K. B. ET AL., ANGEW. CHEM. INT. ED., vol. 40, 2015, pages 2004
BERTOZZI C. R. ET AL., SCIENCE, vol. 291, 2001, pages 2357
BERTOZZI C. R. ET AL., NATURE CHEMICAL BIOLOGY, vol. 1, 2005, pages 13
G. J. L. BERNARDES ET AL., CHEM. REV., vol. 115, 2015, pages 2174
G. J. L. BERNARDES ET AL., CHEM. ASIAN. J., vol. 4, 2009, pages 630
B. G. DAVIES ET AL., NAT. COMMUN., vol. 5, 2014, pages 4740
A. WAGNER ET AL., BIOCONJUGATE. CHEM., vol. 25, 2014, pages 825
DUBOWCHIK ET AL., PHARM. THERAPEUTICS, vol. 83, 1999, pages 67 - 123
JAGATH R JUNUTULA ET AL., NATURE BIOTECHNOLOGY, vol. 26, no. 8, 2008, pages 925 - 932
Attorney, Agent or Firm:
SAKAI INTERNATIONAL PATENT OFFICE (JP)
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