Title:
COMPOUND HAVING THERAPEUTIC EFFICACY FOR LIVER DISEASE
Document Type and Number:
WIPO Patent Application WO/2021/088999
Kind Code:
A1
Abstract:
A compound having therapeutic efficacy for liver disease. The compound may be the compound as represented by formula (I), an optical isomer of same, or a pharmaceutically acceptable salt thereof. The compound is applicable in the treatment or prevention of liver disease and has excellent application prospects specifically in terms of medicaments for treating or preventing fatty liver, hepatic fibrosis or hepatic cirrhosis.
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Inventors:
SHI DONGFANG (CN)
GONG WEIWEI (CN)
YANG YAN (CN)
ZHANG MIN (CN)
FU CHANGJIN (CN)
GU JIE (CN)
LI PENGFEI (CN)
GONG WEIWEI (CN)
YANG YAN (CN)
ZHANG MIN (CN)
FU CHANGJIN (CN)
GU JIE (CN)
LI PENGFEI (CN)
Application Number:
PCT/CN2020/127189
Publication Date:
May 14, 2021
Filing Date:
November 06, 2020
Export Citation:
Assignee:
JIANGSU ATOM BIOSCIENCE AND PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K31/357; C07D407/04; A61P1/16; C07D407/14
Foreign References:
| CN110183431A | 2019-08-30 | |||
| CN110294732A | 2019-10-01 | |||
| CN105037337A | 2015-11-11 | |||
| CN109265434A | 2019-01-25 |
Other References:
GAZAK, R. ; SEDMERA, P. ; VRBACKY, M. ; VOSTALOVA, J. ; DRAHOTA, Z. ; MARHOL, P. ; WALTEROVA, D. ; KREN, V.: "Molecular mechanisms of silybin and 2,3-dehydrosilybin antiradical activity-role of individual hydroxyl groups", FREE RADICAL BIOLOGY & MEDICINE, ELSEVIER INC, US, vol. 46, no. 6, 15 March 2009 (2009-03-15), US, pages 745 - 758, XP025962324, ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2008.11.016
SYED G. A. MOINUDDIN, MICHAL JOURDES, DHRUBOJYOTI D. LASKAR, CHANYOUNG KI, CLAUDIA L. CARDENAS, KYE-WON KIM, DIANZHONG ZHANG, LAUR: "Insights into lignin primary structure and deconstruction from Arabidopsis thaliana COMT (caffeic acid O-methyl transferase) mutant Atomt1", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 8, no. 17, 1 January 2010 (2010-01-01), pages 3928, XP055337139, ISSN: 1477-0520, DOI: 10.1039/c004817h
SYED G. A. MOINUDDIN, MICHAL JOURDES, DHRUBOJYOTI D. LASKAR, CHANYOUNG KI, CLAUDIA L. CARDENAS, KYE-WON KIM, DIANZHONG ZHANG, LAUR: "Insights into lignin primary structure and deconstruction from Arabidopsis thaliana COMT (caffeic acid O-methyl transferase) mutant Atomt1", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 8, no. 17, 1 January 2010 (2010-01-01), pages 3928, XP055337139, ISSN: 1477-0520, DOI: 10.1039/c004817h
Attorney, Agent or Firm:
NANJING SITUO INTELLECTUAL PROPERTY AGENCY (GP) (CN)
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