Title:
COMPOUND FOR INDUCING STEM CELL-LIKE MEMORY CELL IN VITRO, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/246820
Kind Code:
A1
Abstract:
Provided are a compound for inducing a stem cell-like memory cell in vitro, and an application thereof. The compound is as shown in the following formula (I) or (II), and has glycogen synthase kinase 3 inhibitory activity. After combined use of the compound with a cytokine, the absolute number and the formation proportion of stem cell-like memory CD8+T cells are effectively improved, in-vitro amplification of the stem cell-like memory cells is promoted, and the safety is good.
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Inventors:
ZHAO YANGBING (CN)
LIU XIAOJUN (CN)
SONG XIAODONG (CN)
ZHOU YUFAN (CN)
LIU XIAOJUN (CN)
SONG XIAODONG (CN)
ZHOU YUFAN (CN)
Application Number:
PCT/CN2023/101528
Publication Date:
December 28, 2023
Filing Date:
June 20, 2023
Export Citation:
Assignee:
UTC THERAPEUTICS SHANGHAI CO LTD (CN)
International Classes:
C12N5/0783; A61K31/4745; A61K35/17
Foreign References:
| CN105543169A | 2016-05-04 | |||
| CN108473961A | 2018-08-31 | |||
| CN110958882A | 2020-04-03 | |||
| US20160375006A1 | 2016-12-29 | |||
| CN106399243A | 2017-02-15 |
Other References:
WAGNER,F.F. ET AL.: "Exploiting an Asp-Glu “switch” in glycogen synthase kinase 3 to design paralog selective inhibitors for use in acute myeloid leukemia", SCI TRANSL MED., vol. 10, no. 431, 7 March 2018 (2018-03-07), XP055893087, DOI: 10.1126/scitranslmed.aam8460
GATTINONI,L. ET AL.: "Wnt signaling arrests effector T cell differentiation and generates CD8 + memory stem cells", NAT MED., vol. 15, no. 7, 31 July 2009 (2009-07-31), pages 808 - 813, XP037922223, DOI: 10.1038/nm.1982
GATTINONI,L. ET AL.: "Wnt signaling arrests effector T cell differentiation and generates CD8 + memory stem cells", NAT MED., vol. 15, no. 7, 31 July 2009 (2009-07-31), pages 808 - 813, XP037922223, DOI: 10.1038/nm.1982
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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