COMPOUND INHIBITING DIPEPTIDYL PEPTIDASE IV

Title:

COMPOUND INHIBITING DIPEPTIDYL PEPTIDASE IV

Document Type and Number:

WIPO Patent Application WO/2004/067509

Kind Code:

A1

Abstract:

A dipeptidyl peptidase IV inhibitor which is satisfactory in activity, stability, and safety and has excellent medicinal activity. It is a compound represented by the following general formula or a pharmaceutically acceptable salt thereof. (I) [R¹ and R² each represents hydrogen, optionally substituted C_1-6 alkyl, or -COOR⁵ or R¹ and R² form a 3- to 6-membered cycloalkyl in cooperation with the carbon atom bonded thereto; R⁵ represents hydrogen or optionally substituted C_1-6 alkyl; R³ represents hydrogen or optionally substituted C_6-10 aryl; R⁴ represents hydrogen or cyano; D represents -CONR⁶-, -CO-, or -NR⁶CO-; R⁶ represents hydrogen or optionally substituted C_1-6 alkyl; E represents -(CH₂)_m- (m is an integer of 1 to 3), -CH₂OCH₂-, or -SCH₂-; n is an integer of 0 to 3; and A represents an optionally substituted bicyclic heterocyclic group or bicyclic hydrocarbon group.]

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Inventors:

KAKIGAMI TAKUJI (JP)
OKA MITSURU (JP)
KATOH NORIYASU (JP)
YOSHIDA MASAHIRO (JP)
SHIRAI MASAHIRO (JP)
MURASE TORU (JP)
SAKAIRI MASAO (JP)
YAMAMOTO TAKAYO (JP)
TAKEUCHI MITSUAKI (JP)
HAYASHI YUJI (JP)
TAKEDA MOTOHIRO (JP)
MAKINO MITSUHIRO (JP)

Application Number:

PCT/JP2004/000886

Publication Date:

August 12, 2004

Filing Date:

January 30, 2004

Export Citation:

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Assignee:

SANWA KAGAKU KENKYUSHO CO (JP)
KAKIGAMI TAKUJI (JP)
OKA MITSURU (JP)
KATOH NORIYASU (JP)
YOSHIDA MASAHIRO (JP)
SHIRAI MASAHIRO (JP)
MURASE TORU (JP)
SAKAIRI MASAO (JP)
YAMAMOTO TAKAYO (JP)
TAKEUCHI MITSUAKI (JP)
HAYASHI YUJI (JP)
TAKEDA MOTOHIRO (JP)
MAKINO MITSUHIRO (JP)

International Classes:

A61P3/10; A61P43/00; C07D207/16; (IPC1-7): C07D207/16; C07D401/12; C07D403/12; C07D413/12; C07D417/12; C07D471/04; C07D473/34; C07D487/04; C07D495/04; A61K31/40; A61K31/404; A61K31/423; A61K31/427; A61K31/428; A61K31/437; A61K31/4709; A61K31/4725; A61K31/519; A61K31/52; A61K31/4184; A61K31/4035; A61P3/10; A61P43/00

Domestic Patent References:

WO2002051836A1	2002-07-04
WO1998019998A2	1998-05-14

Other References: