Title:
COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/032501
Kind Code:
A1
Abstract:
Provided are a compound of formula 0, a stereoisomer thereof, a tautomer thereof, a geometric isomer thereof, an enantiomer thereof, a diastereomer thereof, a racemate thereof, a polymorph thereof, a solvate thereof, a hydrate thereof, an N-oxide thereof, an isotopically labeled compound thereof, a metabolite thereof, an ester thereof, a prodrug thereof, and a pharmaceutically acceptable salt thereof. In formula 0, ring B is a 5- to 10-membered spiro ring or a 5- to 10-membered spiro heterocyclic ring. The 5- to 10-membered spiro ring and the 5- to 10-membered spiro heterocyclic ring are optionally substituted with 1-5 R1F. The compound can significantly weaken the integrated stress response (ISR) of cells and activate the activity of eIF2B, so that proteins in the cells tend to be synthesized normally. ![]()
Inventors:
CAO BIN (CN)
ZHAO LIYU (CN)
DOU GUOSHENG (CN)
LU SIZHU (CN)
YANG JUN (CN)
CHEN ZHAOQIANG (CN)
ZHANG QIHUA (CN)
WANG SHAOHUI (CN)
CHEN BIN (CN)
ZHANG PEIYU (CN)
ZHAO LIYU (CN)
DOU GUOSHENG (CN)
LU SIZHU (CN)
YANG JUN (CN)
CHEN ZHAOQIANG (CN)
ZHANG QIHUA (CN)
WANG SHAOHUI (CN)
CHEN BIN (CN)
ZHANG PEIYU (CN)
Application Number:
PCT/CN2023/111229
Publication Date:
February 15, 2024
Filing Date:
August 04, 2023
Export Citation:
Assignee:
SHENZHEN ZHONGGE BIOLOGICAL TECH CO LTD (CN)
International Classes:
C07D417/14; A61K31/4178; A61K31/445; A61P25/00; A61P25/28; C07D271/113; C07D413/14
Domestic Patent References:
| WO2019078968A2 | 2019-04-25 |
Foreign References:
| CN113518618A | 2021-10-19 | |||
| US20210130308A1 | 2021-05-06 | |||
| US20100130477A1 | 2010-05-27 | |||
| CN111263752A | 2020-06-09 |
Other References:
DATABASE Registry CAS; 5 January 2022 (2022-01-05), ANONYMOUS : "1H-Pyrrole-2-carboxamide, N-[6- [(1-ethyl-1H-pyrazol-5-yl)car bonyl]-6- azaspiro[2.5]oct-1-yl]-1-met hyl-", XP093138485, retrieved from STN Database accession no. 2755298-21-4
DATABASE Registry CAS; 26 September 2021 (2021-09-26), ANONYMOUS : "Methanone, (1-ethyl-3-pyrazolidi nyl)[7-(4-morpholinyl)-5-oxa -2- azaspiro[3.4]oct-2-yl]Methanone, (1-ethyl-3-pyrazolidi nyl)[7-(4-morpholinyl)-5-oxa -2- azaspiro[3.4]oct-2-yl]", XP093138482, retrieved from STN Database accession no. 2700327-46-2
DATABASE Registry CAS; 23 April 2021 (2021-04-23), ANONYMOUS : "1H-Pyrazole-4-carboxamide, 5-c hloro-N-[7-[(4,6-dimethyl-2- pyridinyl)carbonyl]-7-azaspi ro[3.5]non-2-yl]-1,3-dimethy l-", XP093138479, retrieved from STN Database accession no. 2637340-72-6
DATABASE Registry CAS; 23 April 2021 (2021-04-23), ANONYMOUS : "8-Isoquinolinecarboxamide, N- [2-[(3,6-dimethyl-2-pyridiny l)carbonyl]-2- azaspiro[3.5]non-7-yl]-6-flu oro- ", XP093138473, retrieved from STN Database accession no. 2637340-37-3
DATABASE Registry CAS; 26 September 2021 (2021-09-26), ANONYMOUS : "Methanone, (1-ethyl-3-pyrazolidi nyl)[7-(4-morpholinyl)-5-oxa -2- azaspiro[3.4]oct-2-yl]Methanone, (1-ethyl-3-pyrazolidi nyl)[7-(4-morpholinyl)-5-oxa -2- azaspiro[3.4]oct-2-yl]", XP093138482, retrieved from STN Database accession no. 2700327-46-2
DATABASE Registry CAS; 23 April 2021 (2021-04-23), ANONYMOUS : "1H-Pyrazole-4-carboxamide, 5-c hloro-N-[7-[(4,6-dimethyl-2- pyridinyl)carbonyl]-7-azaspi ro[3.5]non-2-yl]-1,3-dimethy l-", XP093138479, retrieved from STN Database accession no. 2637340-72-6
DATABASE Registry CAS; 23 April 2021 (2021-04-23), ANONYMOUS : "8-Isoquinolinecarboxamide, N- [2-[(3,6-dimethyl-2-pyridiny l)carbonyl]-2- azaspiro[3.5]non-7-yl]-6-flu oro- ", XP093138473, retrieved from STN Database accession no. 2637340-37-3
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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