COMPOUND SERVING AS DDR1 KINASE INHIBITOR, AND MEDICINE

Title:

COMPOUND SERVING AS DDR1 KINASE INHIBITOR, AND MEDICINE

Document Type and Number:

WIPO Patent Application WO/2023/210599

Kind Code:

A1

Abstract:

The present invention provides a compound represented by general formula[1] and having a DDR1 kinase inhibitory activity, a pharmaceutically acceptable salt of the compound, or a solvate of the compound or the pharmaceutically acceptable salt (in the formula, R1 represents a hydrogen atom, a halogen atom, an optionally substituted alkyl group; Het represents a 5- to 10-membered heteroaryl group; L1 represents -CO-NH- or -CRa=CRb-; X represents C-Rc; R2 represents a C1-C6 haloalkoxy group or a C1-C6 haloalkyl group; R3, R4 and a carbon atom to which these residues are bound together form an optionally substituted C3-C6 cycloalkyl group or an optionally substituted heterocycloalkyl group).

More Like This:

WO/1993/003018	COMPOUNDS HAVING ANGIOTENSINE II ANTAGONISTIC ACTIVITY
JPH11508227	INDUSTRIAL APPLICABILITY [Hetero) Aryloxy-,-thio- and-aminocrotonic acid esters, methods for producing and using the same
JP2018526338	Substituted aryl and heteroarylcarboxylic acid hydrazides or salts thereof and their use for enhancing stress tolerance of plants

Inventors:

ZAIMOKU HISAAKI (JP)
ASADA JUNSHI (JP)
HASHIMOTO KOSUKE (JP)
HONDA YOHEI (JP)
TSUZUKI YOTA (JP)
KOSUGI KEIJI (JP)

Application Number:

PCT/JP2023/016163

Publication Date:

November 02, 2023

Filing Date:

April 24, 2023

Export Citation:

Click for automatic bibliography generation Help

Assignee:

NIPPON SHINYAKU CO LTD (JP)

International Classes:

C07D239/26; A61K31/415; A61K31/421; A61K31/426; A61K31/437; A61K31/44; A61K31/4965; A61K31/505; A61P11/00; A61P13/12; A61P19/02; A61P35/00; A61P35/02; A61P43/00; C07D213/61; C07D213/65; C07D213/82; C07D231/12; C07D239/42; C07D239/47; C07D241/20; C07D263/34; C07D277/56; C07D401/06; C07D471/04

Domestic Patent References:

WO2010062038A2	2010-06-03
WO2011090738A2	2011-07-28

Foreign References:

JP2014528903A

2014-10-30

Other References:

JIANMING ZHANG, FRANCISCO J. ADRIáN, WOLFGANG JAHNKE, SANDRA W. COWAN-JACOB, ALLEN G. LI, ROXANA E. IACOB, TAEBO SIM, JOHN PO: "Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors", NATURE, vol. 463, 28 January 2010 (2010-01-28), pages 501 - 506, XP055177766, DOI: 10.1038/nature08675

Attorney, Agent or Firm:

YAMAO, Norihito et al. (JP)

Download PDF:

View/Download PDF PDF Help

Previous Patent: INFORMATION PROCESSING SYSTEM, INFORMATION PROCESSING METHOD, AND PROGRAM

Next Patent: FILTER COMPONENT