Title:
COMPOUND SERVING AS IRAK INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2020/135513
Kind Code:
A1
Abstract:
The present invention relates to a compound serving as an IRAK inhibitor. Specifically, the present invention provides a compound, or a cis-trans-isomer, an optical isomer or raceme thereof, or a pharmaceutically acceptable salt, a prodrug, a deuterated derivative, or a hydrate, or a solvate thereof. The compound has the structure as shown in formula I. The compound has an effective inhibiting effect to IRAK, and thus has a therapeutic effect to IRAK-related diseases. (I)
Inventors:
FENG YAN (CN)
YE GUOZHONG (CN)
LI SHIQIANG (CN)
HU ZHILONG (CN)
WANG CHAODONG (CN)
YE GUOZHONG (CN)
LI SHIQIANG (CN)
HU ZHILONG (CN)
WANG CHAODONG (CN)
Application Number:
PCT/CN2019/128347
Publication Date:
July 02, 2020
Filing Date:
December 25, 2019
Export Citation:
Assignee:
SHANGHAI MEIYUE BIOTECH DEV CO LTD (CN)
International Classes:
A61K31/416; C07D405/14; A61K31/4439; A61K31/4545; A61K31/497; A61K31/498; A61K31/519; A61P1/00; A61P3/00; A61P9/10; A61P11/06; A61P17/06; A61P19/02; A61P19/06; A61P29/00; A61P31/04; A61P35/00; A61P37/00; A61P37/02; A61P37/08; C07D231/56; C07D401/12; C07D401/14; C07D403/12; C07D471/04; C07D487/04
Domestic Patent References:
| WO2017108744A1 | 2017-06-29 |
Foreign References:
| CN107406416A | 2017-11-28 | |||
| CN108026065A | 2018-05-11 | |||
| CN107872977A | 2018-04-03 | |||
| CN201811593893A | 2018-12-25 |
Other References:
FLANNERY, BIOCHEM. PHARMACOL., vol. 80, no. 12, 2010, pages 1981 - 1991
PRISCILLA N, J. EXP. MED., vol. 13, no. 212, 2015, pages 2189 - 2201
CHAUDHARY D, J. MED. CHEM., vol. 58, no. 1, 2015, pages 96 - 110
See also references of EP 3889150A4
PRISCILLA N, J. EXP. MED., vol. 13, no. 212, 2015, pages 2189 - 2201
CHAUDHARY D, J. MED. CHEM., vol. 58, no. 1, 2015, pages 96 - 110
See also references of EP 3889150A4
Attorney, Agent or Firm:
BEIJING ORIGINTELLIGENCE IP LAW FIRM et al. (CN)
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