Title:
COMPOUND SERVING AS MASP-2 INHIBITOR, PHARMACEUTICAL COMPOSITION, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/143401
Kind Code:
A1
Abstract:
The present invention relates to a compound having inhibitory activity for the lectin pathway of complement, a preparation method therefor, and an application thereof. Specifically, the present invention relates to a compound as represented by general formula (I'), a pharmaceutically acceptable salt thereof, a preparation method therefor, and an application thereof as a MASP-2 inhibitor, particularly an application in the preparation of a drug for treating diseases such as IgA nephropathy, TA-TMA, aHUS, and lupus nephritis.
Inventors:
LOU JUN (CN)
WU JINGKANG (CN)
ZHOU FENG (CN)
LIU LI (CN)
DONG XIAOLONG (CN)
CHEN YING (CN)
ZHANG LIQIAN (CN)
ZHANG YIHAN (CN)
CHEN YONGKAI (CN)
WANG CHAODONG (CN)
WU JINGKANG (CN)
ZHOU FENG (CN)
LIU LI (CN)
DONG XIAOLONG (CN)
CHEN YING (CN)
ZHANG LIQIAN (CN)
ZHANG YIHAN (CN)
CHEN YONGKAI (CN)
WANG CHAODONG (CN)
Application Number:
PCT/CN2023/073238
Publication Date:
August 03, 2023
Filing Date:
January 19, 2023
Export Citation:
Assignee:
WUHAN LL SCIENCE AND TECH DEVELOPMENT CO LTD (CN)
International Classes:
C07D401/12; A61K31/513; A61K31/662; A61P9/00; A61P13/00; C07D493/04
Domestic Patent References:
| WO2005040355A2 | 2005-05-06 | |||
| WO2021178780A1 | 2021-09-10 | |||
| WO2021113690A1 | 2021-06-10 | |||
| WO2019231935A1 | 2019-12-05 | |||
| WO2021113682A1 | 2021-06-10 |
Other References:
DATABASE Registry 19 December 2022 (2022-12-19), ANONYMOUS : "1H-Pyrazole-4-carboxamide, 3-(4-chlorophenyl)-N-[2-[(3,4-dihydro-2H-1- benzopyran-4-yl)amino]-2-oxoethyl]- (CA INDEX NAME)", XP093083251, retrieved from STNext Database accession no. 2871235-66-2
DATABASE Registry 10 November 2021 (2021-11-10), "1H-Pyrazole-4-carboxamide, N-[2-[(3,4-dihydro-2H-1-benzopyran-4-yl)amino]- 2-oxoethyl]-1-methyl-5-(phenylmethyl)- (CA INDEX NAME)", XP093083252, retrieved from STNext Database accession no. 2728393-75-5
"CAS-RN: 1626789-22-7", REGISTRY, 26 September 2014 (2014-09-26)
"CAS-RN: 1300869-99-1", REGISTRY, 26 May 2011 (2011-05-26)
"CAS-RN: 1299153-31-3", REGISTRY, 24 May 2011 (2011-05-24)
"CAS-RN: 1279637-39-6", REGISTRY, 13 April 2011 (2011-04-13)
"CAS-RN: 2224044-44-2", REGISTRY, 20 May 2018 (2018-05-20)
"CAS-RN: 1219390-79-0", REGISTRY, 16 April 2010 (2010-04-16)
"CAS-RN: 1098783-43-7", REGISTRY, 1 February 2009 (2009-02-01)
"CAS-RN: 1047457-63-5", REGISTRY, 8 September 2008 (2008-09-08)
"CAS-RN: 1014041-96-3", REGISTRY, 13 April 2008 (2008-04-13)
"CAS-RN: 1014023-46-1", REGISTRY, 13 April 2008 (2008-04-13)
"CAS-RN: 2096419-55-3", REGISTRY, 19 May 2017 (2017-05-19)
"CAS-RN: 1502182-48-0", REGISTRY, 24 December 2013 (2013-12-24)
"CAS-RN: 1273654-95-7", REGISTRY, 3 April 2011 (2011-04-03)
"CAS-RN: 1822777-78-5", REGISTRY, 4 December 2015 (2015-12-04)
"CAS-RN: 1605067-78-4", REGISTRY, 14 May 2014 (2014-05-14)
"CAS-RN: 1837947-53-1", REGISTRY, 28 December 2015 (2015-12-28)
DATABASE Registry 10 November 2021 (2021-11-10), "1H-Pyrazole-4-carboxamide, N-[2-[(3,4-dihydro-2H-1-benzopyran-4-yl)amino]- 2-oxoethyl]-1-methyl-5-(phenylmethyl)- (CA INDEX NAME)", XP093083252, retrieved from STNext Database accession no. 2728393-75-5
"CAS-RN: 1626789-22-7", REGISTRY, 26 September 2014 (2014-09-26)
"CAS-RN: 1300869-99-1", REGISTRY, 26 May 2011 (2011-05-26)
"CAS-RN: 1299153-31-3", REGISTRY, 24 May 2011 (2011-05-24)
"CAS-RN: 1279637-39-6", REGISTRY, 13 April 2011 (2011-04-13)
"CAS-RN: 2224044-44-2", REGISTRY, 20 May 2018 (2018-05-20)
"CAS-RN: 1219390-79-0", REGISTRY, 16 April 2010 (2010-04-16)
"CAS-RN: 1098783-43-7", REGISTRY, 1 February 2009 (2009-02-01)
"CAS-RN: 1047457-63-5", REGISTRY, 8 September 2008 (2008-09-08)
"CAS-RN: 1014041-96-3", REGISTRY, 13 April 2008 (2008-04-13)
"CAS-RN: 1014023-46-1", REGISTRY, 13 April 2008 (2008-04-13)
"CAS-RN: 2096419-55-3", REGISTRY, 19 May 2017 (2017-05-19)
"CAS-RN: 1502182-48-0", REGISTRY, 24 December 2013 (2013-12-24)
"CAS-RN: 1273654-95-7", REGISTRY, 3 April 2011 (2011-04-03)
"CAS-RN: 1822777-78-5", REGISTRY, 4 December 2015 (2015-12-04)
"CAS-RN: 1605067-78-4", REGISTRY, 14 May 2014 (2014-05-14)
"CAS-RN: 1837947-53-1", REGISTRY, 28 December 2015 (2015-12-28)
Attorney, Agent or Firm:
BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)
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