Title:
COMPOUND FOR SHP2 PROTEIN DEGRADATION AND MEDICAL USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/085699
Kind Code:
A1
Abstract:
The present disclosure provides a compound of a specific chemical structure, an optical isomer, stereoisomer, isotopic variant, hydrate or solvate thereof, or a pharmaceutically acceptable salt thereof, which has excellent activity in terms of degradation of SHP2 protein. The present disclosure also provides a composition comprising such a compound, an optical isomer, stereoisomer, isotopic variant, hydrate or solvate thereof, or a pharmaceutically acceptable salt thereof. The present disclosure also provides medical uses of a composition comprising the compound according to the present disclosure, an optical isomer, stereoisomer, isotopic variant, hydrate or solvate thereof, or a pharmaceutically acceptable salt thereof, for the treatment or prevention of SHP2-associated diseases (for example, cancer). The present disclosure also provides a method for treating or preventing SHP2-associated diseases (for example, cancer), the method comprising administering, to an individual in need of treatment, an effective amount of a composition comprising the compound according to the present disclosure, an optical isomer, stereoisomer, isotopic variant, hydrate or solvate thereof, or a pharmaceutically acceptable salt thereof.
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Inventors:
RYU JE HO (KR)
LEE JI HYE (KR)
AHN JUNG MIN (KR)
BAE ONNURI (KR)
HAN JEONG HWA (KR)
LEE SONG HEE (KR)
KIM JI YOUNG (KR)
KIM HYUN HWI (KR)
LEE SOO HYUN (KR)
PARK JI YOUN (KR)
KIM SO HYUN (KR)
SONG JI YOUNG (KR)
SAGONG HYE YEON (KR)
KIM JUNG EUN (KR)
JUNG JI EUN (KR)
HONG BEOM JIN (KR)
PARK GEON TAE (KR)
LIM SEONA (KR)
SHIN YONG JE (KR)
MOON MI JIN (KR)
LEE DONG HO (KR)
NA JUNG TAE (KR)
LIM YE SEUL (KR)
WOO YAE JIN (KR)
KANG JU YOUNG (KR)
LEE JI HYE (KR)
AHN JUNG MIN (KR)
BAE ONNURI (KR)
HAN JEONG HWA (KR)
LEE SONG HEE (KR)
KIM JI YOUNG (KR)
KIM HYUN HWI (KR)
LEE SOO HYUN (KR)
PARK JI YOUN (KR)
KIM SO HYUN (KR)
SONG JI YOUNG (KR)
SAGONG HYE YEON (KR)
KIM JUNG EUN (KR)
JUNG JI EUN (KR)
HONG BEOM JIN (KR)
PARK GEON TAE (KR)
LIM SEONA (KR)
SHIN YONG JE (KR)
MOON MI JIN (KR)
LEE DONG HO (KR)
NA JUNG TAE (KR)
LIM YE SEUL (KR)
WOO YAE JIN (KR)
KANG JU YOUNG (KR)
Application Number:
PCT/KR2023/016301
Publication Date:
April 25, 2024
Filing Date:
October 19, 2023
Export Citation:
Assignee:
UBIX THERAPEUTICS INC (KR)
SK BIOPHARMACEUTICALS CO LTD (KR)
SK BIOPHARMACEUTICALS CO LTD (KR)
International Classes:
C07D417/14; A61K31/497; A61P35/00; A61P35/02; C07D471/10; C07D491/107
Attorney, Agent or Firm:
PHIL & ONZI INT'L PATENT & LAW FIRM (KR)
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