Title:
COMPOUND FOR TREATING CARTILAGE DISORDERS
Document Type and Number:
WIPO Patent Application WO/2013/021935
Kind Code:
A1
Abstract:
The present invention provides a compound which can be injected into a joint cavity which is an affected part of cartilage disorders and can be accumulated in the joint cavity to exert the pharmacological effect thereof in a sustained manner, for the purpose of ameliorating cartilage disorders without developing any adverse side effect. The active form of the compound is represented by general formula (A). A compound according to the present invention, which is represented by general formula (I) (wherein all of symbols are as defined in the description), is a compound that can achieve the above-mentioned purpose. This compound does not exhibit any adverse side effect on the cardiovascular system even when the compound is administered in an effective amount for exhibiting a cartilage regeneration activity, and is therefore extremely useful as a safe and effective prophylactic and/or therapeutic agent for cartilage disorders. A suspension produced using this compound can be injected into an affected part without requiring the incision of the affected part, can therefore reduce the burden on patients, and is extremely useful as a medicinal agent.
Inventors:
OBITSU TETSUO (JP)
TANI KOUSUKE (JP)
SUGIHARA HIKARU (JP)
NISHIURA AKIO (JP)
FUJIMURA SHINSEI (JP)
TANI KOUSUKE (JP)
SUGIHARA HIKARU (JP)
NISHIURA AKIO (JP)
FUJIMURA SHINSEI (JP)
Application Number:
PCT/JP2012/069820
Publication Date:
February 14, 2013
Filing Date:
August 03, 2012
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
OBITSU TETSUO (JP)
TANI KOUSUKE (JP)
SUGIHARA HIKARU (JP)
NISHIURA AKIO (JP)
FUJIMURA SHINSEI (JP)
OBITSU TETSUO (JP)
TANI KOUSUKE (JP)
SUGIHARA HIKARU (JP)
NISHIURA AKIO (JP)
FUJIMURA SHINSEI (JP)
International Classes:
C07C405/00; A61K9/10; A61K31/5575; A61K47/10; A61K47/26; A61K47/34; A61K47/36; A61K47/40; A61K47/44; A61P19/08; C07C69/732; C07C69/92; C07C235/16
Domestic Patent References:
| WO2005009468A1 | 2005-02-03 |
Foreign References:
| JPH11193268A | 1999-07-21 | |||
| JPH06227985A | 1994-08-16 | |||
| JPH11180949A | 1999-07-06 | |||
| EP0860430A2 | 1998-08-26 | |||
| JP2007099760A | 2007-04-19 | |||
| JPS503362A | 1975-01-14 | |||
| JPS5231404A | 1977-03-09 | |||
| JPS6152146A | 1986-03-14 |
Other References:
SYNLETT, vol. 1, 2002, pages 239 - 242
RICHARD C. LAROCK: "Comprehensive Organic Transformations : A Guide to Functional Group Preparations", 1999, JOHN WILEY & SONS INC
RICHARD C. LAROCK: "Comprehensive Organic Transformations: A Guide to Functional Group Preparations", 1999, JOHN WILEY & SONS INC
ELMER J. RAUCKMAN, J. ORG. CHERN., vol. 41, no. 3, 1976, pages 564 - 565
See also references of EP 2740724A4
RICHARD C. LAROCK: "Comprehensive Organic Transformations : A Guide to Functional Group Preparations", 1999, JOHN WILEY & SONS INC
RICHARD C. LAROCK: "Comprehensive Organic Transformations: A Guide to Functional Group Preparations", 1999, JOHN WILEY & SONS INC
ELMER J. RAUCKMAN, J. ORG. CHERN., vol. 41, no. 3, 1976, pages 564 - 565
See also references of EP 2740724A4
Attorney, Agent or Firm:
IWATANI, Ryo (JP)
Tatsu Iwatani (JP)
Tatsu Iwatani (JP)
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Claims:
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