Title:
COMPOUND FOR TREATING METABOLIC DISEASES AND PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/119832
Kind Code:
A1
Abstract:
Provided are a compound for treating metabolic diseases having the structure as shown in formula (I) or formula (II), or a racemate, stereoisomer, geometric isomer, tautomer, solvate, hydrate, metabolite, pharmaceutically acceptable salt or prodrug thereof. The compound is an activator of FXR and/or a TGR5 receptor, and thus has the activity of activating FXR and/or a TGR5 receptor, and can be used in the preparation of drugs for treating chronic liver diseases, metabolic diseases or portal hypertension.
Inventors:
FU GUOQIN (CN)
DING WEI (CN)
YIN BO (CN)
YANG CHAO (CN)
WANG CUIQIN (CN)
DOU YONG (CN)
WANG RUILING (CN)
DING WEI (CN)
YIN BO (CN)
YANG CHAO (CN)
WANG CUIQIN (CN)
DOU YONG (CN)
WANG RUILING (CN)
Application Number:
PCT/CN2018/100663
Publication Date:
June 27, 2019
Filing Date:
August 15, 2018
Export Citation:
Assignee:
XI AN BIOCARE PHARMA LTD (CN)
International Classes:
C07J9/00; A61K31/575; A61K31/58; A61P1/16; A61P3/00; C07J41/00
Domestic Patent References:
| WO2016173524A1 | 2016-11-03 | |||
| WO2017062763A1 | 2017-04-13 | |||
| WO2017147137A1 | 2017-08-31 |
Foreign References:
| US5541348A | 1996-07-30 | |||
| CN104672290A | 2015-06-03 | |||
| CN105593237A | 2016-05-18 | |||
| CN107231795A | 2017-10-03 | |||
| CN201711371702A | 2017-12-19 |
Other References:
See also references of EP 3730509A4
CRAWLEY, EXPERT OPINION THER. PATENTS, vol. 20, no. 8, 2010, pages 1047 - 1057
MCGRAW-HILL: "Dictionary of Chemical Terms", 1984, MCGRAW-HILL BOOK COMPANY
ELIEL, E.WILEN, S.: "Stereochemistry of Organic Compounds", 1994, JOHN WILEY & SONS, INC.
"Remington's Pharmaceutical Sciences", 1985, MACK PUBLISHING COMPANY
STAHLWERMUTH: "Handbook of Pharmaceutical Salts: Properties, Selection, and Use", 2002, WILEY-VCH
CRAWLEY, EXPERT OPINION THER. PATENTS, vol. 20, no. 8, 2010, pages 1047 - 1057
MCGRAW-HILL: "Dictionary of Chemical Terms", 1984, MCGRAW-HILL BOOK COMPANY
ELIEL, E.WILEN, S.: "Stereochemistry of Organic Compounds", 1994, JOHN WILEY & SONS, INC.
"Remington's Pharmaceutical Sciences", 1985, MACK PUBLISHING COMPANY
STAHLWERMUTH: "Handbook of Pharmaceutical Salts: Properties, Selection, and Use", 2002, WILEY-VCH
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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