Title:
COMPOUND AND USE THEREOF IN PREVENTING OR TREATING RADIATION DAMAGE
Document Type and Number:
WIPO Patent Application WO/2023/227054
Kind Code:
A1
Abstract:
The present invention provides a compound and use thereof, particularly a JWA gene agonist and use thereof in preventing or treating radiation damage. The compound, by means of activating JWA gene expression, enhances the DNA repair capacity of cells, and has a good elimination capacity for highly active oxygen species generated by X-ray radiation. The compound can also effectively inhibit cell apoptosis caused by radiation to reduce the damage, and further reduce the generation of free radicals to reduce the probability of radiation damage.
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Inventors:
ZHOU JIANWEI (CN)
ZHOU YAN (CN)
LIU JINGWEN (CN)
LI XIONG (CN)
LI AIPING (CN)
TANG FENG (CN)
HU LIRONG (CN)
YAN YUXI (CN)
XUE TENGFEI (CN)
ZHUANG YINQIANG (CN)
HAO YUANBIN (CN)
ZHOU YAN (CN)
LIU JINGWEN (CN)
LI XIONG (CN)
LI AIPING (CN)
TANG FENG (CN)
HU LIRONG (CN)
YAN YUXI (CN)
XUE TENGFEI (CN)
ZHUANG YINQIANG (CN)
HAO YUANBIN (CN)
Application Number:
PCT/CN2023/096248
Publication Date:
November 30, 2023
Filing Date:
May 25, 2023
Export Citation:
Assignee:
SIMCERE PHARMACEUTICAL CO LTD (CN)
JIANGSU SIMCERE PHARM CO LTD (CN)
JIANGSU SIMCERE PHARM CO LTD (CN)
International Classes:
A61K31/4439; A61K31/4245; A61K45/00; A61P35/00; A61P39/06; A61P43/00
Foreign References:
| CN106632299A | 2017-05-10 | |||
| CN110981865A | 2020-04-10 | |||
| CN110201173A | 2019-09-06 | |||
| CN110437176A | 2019-11-12 |
Other References:
LI YUAN, SHEN XIN, WANG XUEMING, LI AIPING, WANG PENGQI, JIANG PAN, ZHOU JIANWEI, FENG QING: "EGCG regulates the cross-talk between JWA and topoisomerase IIα in non-small-cell lung cancer (NSCLC) cells", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 5, no. 1, 5 June 2015 (2015-06-05), US , pages 11009, XP093112221, ISSN: 2045-2322, DOI: 10.1038/srep11009
王章定等 (WANG, ZHANGDING ET AL.): "激活环境应答基因JWA抑制肿瘤生长与转移的机制研究 (Non-official translation: Study on the Mechanism of Activating Environmental Response Gene JWA to Inhibit Tumor Growth and Metastasis)", 中国毒理学会第七次全国会员代表大会暨中国毒理学会第六次中青年学者科技论坛论文摘要 (NON-OFFICIAL TRANSLATION: ABSTRACTS OF THE 7TH NATIONAL MEMBER CONGRESS OF THE CHINESE SOCIETY OF TOXICOLOGY AND THE 6TH SCIENCE AND TECHNOLOGY FORUM OF YOUNG AND MIDDLE-AGED SCHOLARS OF THE CHINESE SOCIETY O, 31 December 2018 (2018-12-31)
陈瑞 (CHEN, RUI): "JWA参与氧化应激诱导的碱基切除修复信号通路的机制研究 (The Molecular Mechanism of JWA Involved in Base Excision Repair Induced by Oxidative Stress)", 中国博士学位论文全文数据库 医药卫生科技辑 (CHINESE DOCTORAL DISSERTATIONS FULL-TEXT DATABASE, MEDICINE AND HEALTH SCIENCES), no. 02, 15 February 2008 (2008-02-15)
QIANZHOU: "Research Progress on DNA Damage Repair Genes and Radiation-Induced Lung Injury", CHONGQING MEDICINE, vol. 39, no. 21, 15 November 2010 (2010-11-15), pages 2970 - 2973, XP093112222
KANG, Q. ET AL.: "EGCG Enhances Cancer Cells Sensitivity under 60Coγ Radiation Based on miR-34a/Sirt1/p53", FOOD AND CHEMICAL TOXICOLOGY, vol. 133, 5 September 2019 (2019-09-05), XP085840974, DOI: 10.1016/j.fct.2019.110807
YI, J. ET AL.: "Radioprotection of EGCG Based on Immunoregulatory Effect and Antioxidant Activity against 60Coγ Radiation-Induced Injury in Mice", FOOD AND CHEMICAL TOXICOLOGY, vol. 135, 16 December 2019 (2019-12-16), XP085975257, DOI: 10.1016/j.fct.2019.111051
KIM JI-YE, BAHAR ENTAZ, LEE JUNG-YUN, CHANG SUNHEE, KIM SE HOON, PARK EUN YOUNG, DO SUNG-IM, YOON HYONOK, KIM HYUN-SOO: "ARL6IP5 reduces cisplatin-resistance by suppressing DNA repair and promoting apoptosis pathways in ovarian carcinoma", CELL DEATH & DISEASE, NATURE PUBLISHING GROUP, GB, vol. 13, no. 3, 15 March 2022 (2022-03-15), GB , pages 1 - 13, XP093112223, ISSN: 2041-4889, DOI: 10.1038/s41419-022-04568-4
ZHOU YAN, LIU JINGWEN, LI XIONG, WANG LUMAN, HU LIRONG, LI AIPING, ZHOU JIANWEI: "JAC4 Protects from X-ray Radiation-Induced Intestinal Injury by JWA-Mediated Anti-Oxidation/Inflammation Signaling", ANTIOXIDANTS, vol. 11, no. 6, 27 May 2022 (2022-05-27), pages 1067, XP093047845, DOI: 10.3390/antiox11061067
DING KUN, LIU XIA, WANG LUMAN, ZOU LU, JIANG XUQIAN, LI AIPING, ZHOU JIANWEI: "Targeting JWA for Cancer Therapy: Functions, Mechanisms and Drug Discovery", CANCERS, CH, vol. 14, no. 19, 24 September 2022 (2022-09-24), CH , pages 4655, XP093112224, ISSN: 2072-6694, DOI: 10.3390/cancers14194655
DING KUN, JIANG XUQIAN, WANG ZHANGDING, ZOU LU, CUI JIAHUA, LI XIONG, SHU CHUANJUN, LI AIPING, ZHOU JIANWEI: "JAC4 Inhibits EGFR-Driven Lung Adenocarcinoma Growth and Metastasis through CTBP1-Mediated JWA/AMPK/NEDD4L/EGFR Axis", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL (MDPI), BASEL, CH, vol. 24, no. 10, 15 May 2023 (2023-05-15), Basel, CH , pages 8794, XP093112226, ISSN: 1422-0067, DOI: 10.3390/ijms24108794
王章定等 (WANG, ZHANGDING ET AL.): "激活环境应答基因JWA抑制肿瘤生长与转移的机制研究 (Non-official translation: Study on the Mechanism of Activating Environmental Response Gene JWA to Inhibit Tumor Growth and Metastasis)", 中国毒理学会第七次全国会员代表大会暨中国毒理学会第六次中青年学者科技论坛论文摘要 (NON-OFFICIAL TRANSLATION: ABSTRACTS OF THE 7TH NATIONAL MEMBER CONGRESS OF THE CHINESE SOCIETY OF TOXICOLOGY AND THE 6TH SCIENCE AND TECHNOLOGY FORUM OF YOUNG AND MIDDLE-AGED SCHOLARS OF THE CHINESE SOCIETY O, 31 December 2018 (2018-12-31)
陈瑞 (CHEN, RUI): "JWA参与氧化应激诱导的碱基切除修复信号通路的机制研究 (The Molecular Mechanism of JWA Involved in Base Excision Repair Induced by Oxidative Stress)", 中国博士学位论文全文数据库 医药卫生科技辑 (CHINESE DOCTORAL DISSERTATIONS FULL-TEXT DATABASE, MEDICINE AND HEALTH SCIENCES), no. 02, 15 February 2008 (2008-02-15)
QIANZHOU: "Research Progress on DNA Damage Repair Genes and Radiation-Induced Lung Injury", CHONGQING MEDICINE, vol. 39, no. 21, 15 November 2010 (2010-11-15), pages 2970 - 2973, XP093112222
KANG, Q. ET AL.: "EGCG Enhances Cancer Cells Sensitivity under 60Coγ Radiation Based on miR-34a/Sirt1/p53", FOOD AND CHEMICAL TOXICOLOGY, vol. 133, 5 September 2019 (2019-09-05), XP085840974, DOI: 10.1016/j.fct.2019.110807
YI, J. ET AL.: "Radioprotection of EGCG Based on Immunoregulatory Effect and Antioxidant Activity against 60Coγ Radiation-Induced Injury in Mice", FOOD AND CHEMICAL TOXICOLOGY, vol. 135, 16 December 2019 (2019-12-16), XP085975257, DOI: 10.1016/j.fct.2019.111051
KIM JI-YE, BAHAR ENTAZ, LEE JUNG-YUN, CHANG SUNHEE, KIM SE HOON, PARK EUN YOUNG, DO SUNG-IM, YOON HYONOK, KIM HYUN-SOO: "ARL6IP5 reduces cisplatin-resistance by suppressing DNA repair and promoting apoptosis pathways in ovarian carcinoma", CELL DEATH & DISEASE, NATURE PUBLISHING GROUP, GB, vol. 13, no. 3, 15 March 2022 (2022-03-15), GB , pages 1 - 13, XP093112223, ISSN: 2041-4889, DOI: 10.1038/s41419-022-04568-4
ZHOU YAN, LIU JINGWEN, LI XIONG, WANG LUMAN, HU LIRONG, LI AIPING, ZHOU JIANWEI: "JAC4 Protects from X-ray Radiation-Induced Intestinal Injury by JWA-Mediated Anti-Oxidation/Inflammation Signaling", ANTIOXIDANTS, vol. 11, no. 6, 27 May 2022 (2022-05-27), pages 1067, XP093047845, DOI: 10.3390/antiox11061067
DING KUN, LIU XIA, WANG LUMAN, ZOU LU, JIANG XUQIAN, LI AIPING, ZHOU JIANWEI: "Targeting JWA for Cancer Therapy: Functions, Mechanisms and Drug Discovery", CANCERS, CH, vol. 14, no. 19, 24 September 2022 (2022-09-24), CH , pages 4655, XP093112224, ISSN: 2072-6694, DOI: 10.3390/cancers14194655
DING KUN, JIANG XUQIAN, WANG ZHANGDING, ZOU LU, CUI JIAHUA, LI XIONG, SHU CHUANJUN, LI AIPING, ZHOU JIANWEI: "JAC4 Inhibits EGFR-Driven Lung Adenocarcinoma Growth and Metastasis through CTBP1-Mediated JWA/AMPK/NEDD4L/EGFR Axis", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL (MDPI), BASEL, CH, vol. 24, no. 10, 15 May 2023 (2023-05-15), Basel, CH , pages 8794, XP093112226, ISSN: 1422-0067, DOI: 10.3390/ijms24108794
Attorney, Agent or Firm:
JIANGSU SIMCERE PHARMACEUTICAL CO., LTD. (CN)
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