Title:
COMPOUND USED AS WDR5 INHIBITOR OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND USE OF COMPOUND
Document Type and Number:
WIPO Patent Application WO/2024/002379
Kind Code:
A1
Abstract:
Provided are a compound used as a WDR5 inhibitor or a pharmaceutically acceptable salt thereof, and a use of the compound in preparation of a drug. The compound has high affinity to WDR5, and compared with the prior art, has higher inhibitory activity.
More Like This:
| WO/2003/101974 | ARALKYL-ALCOHOL PEIPERAZINE DERIVATIVES AND THEIR USES AS ANTIDEPRESSANT |
| JP4106711 | Aminopyridine derivative |
| WO/2008/084004 | SULFONAMIDE DERIVATIVES AS CHYMASE INHIBITORS |
Inventors:
XU FUMING (CN)
CHEN WENMIN (CN)
LI XIAOGUANG (CN)
ZHOU GUAN (CN)
WANG KANGHUA (CN)
ZHAO QIANQIAN (CN)
CHEN WENMIN (CN)
LI XIAOGUANG (CN)
ZHOU GUAN (CN)
WANG KANGHUA (CN)
ZHAO QIANQIAN (CN)
Application Number:
PCT/CN2023/105609
Publication Date:
January 04, 2024
Filing Date:
July 03, 2023
Export Citation:
Assignee:
GAN & LEE PHARM CO LTD (CN)
International Classes:
C07D401/12; A61K31/495; A61K31/496; A61P35/02; C07D241/04; C07D401/10; C07D401/14; C07D403/10; C07D403/14; C07D405/10; C07D405/12; C07D413/14; C07D471/10
Domestic Patent References:
| WO2017147701A1 | 2017-09-08 |
Foreign References:
| CN108715585A | 2018-10-30 | |||
| CN111372926A | 2020-07-03 | |||
| CN109195965A | 2019-01-11 | |||
| CN105175284A | 2015-12-23 |
Other References:
CHEN WEILIN; CHEN XIN; LI DONGDONG; WANG XIANGHAN; LONG GUANLU; JIANG ZHENGYU; YOU QIDONG; GUO XIAOKE: "Discovery of a potent MLL1 and WDR5 protein-protein interaction inhibitor with in vivo antitumor activity", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 223, 28 June 2021 (2021-06-28), AMSTERDAM, NL , XP086778590, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2021.113677
Download PDF: