Title:
COMPOUND WITH AMYLOID AFFINITY
Document Type and Number:
WIPO Patent Application WO/2005/042461
Kind Code:
A1
Abstract:
A novel technology capable of detection of amyloids, such as Aβ-protein occurring in Alzheimer disease, without the need for any special facilities. There is disclosed a styrylbenzene compound of the general formula (I). each of R1 and R2 independently is hydroxyl or carboxyl, and R3 is a fluorine or bromine atom. Necessarily when R3 is a bromine atom and optionally when R3 is a fluorine atom, at least one carbon atom among the carbon atoms constituting the carboxyls represented by R1 and R2 and the carbon atoms on &agr -, β-, &gammad - and &dgr -positions is 13C. The compound of the formula (I) is not only capable of conducting fluorescent staining of amyloids but also functions as an amyloid-specific MRI contrast agent.
Inventors:
SAIDO TAKAOMI (JP)
HIGUCHI MAKOTO (JP)
IWATA NOBUHISA (JP)
SASAMOTO KAZUMI (JP)
SATO KUMI (JP)
HIGUCHI MAKOTO (JP)
IWATA NOBUHISA (JP)
SASAMOTO KAZUMI (JP)
SATO KUMI (JP)
Application Number:
PCT/JP2004/016101
Publication Date:
May 12, 2005
Filing Date:
October 29, 2004
Export Citation:
Assignee:
DOJINDO LAB (JP)
RIKEN (JP)
SAIDO TAKAOMI (JP)
HIGUCHI MAKOTO (JP)
IWATA NOBUHISA (JP)
SASAMOTO KAZUMI (JP)
SATO KUMI (JP)
RIKEN (JP)
SAIDO TAKAOMI (JP)
HIGUCHI MAKOTO (JP)
IWATA NOBUHISA (JP)
SASAMOTO KAZUMI (JP)
SATO KUMI (JP)
International Classes:
A61K49/00; A61K49/10; C09B23/14; (IPC1-7): C07C65/19; A61K49/00; C09B23/00
Domestic Patent References:
| WO2002016333A2 | 2002-02-28 |
Other References:
LEE C.W. ET AL.: "Isomerization of (Z,Z) to (E,E)1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene in strong base: probes for amyloid plaques in the brain", JOURNAL OF MEDICINAL CHEMISTRY, vol. 44, no. 14, 2001, pages 2270 - 2275, XP002958808
Attorney, Agent or Firm:
Tsutsui, Satoru (3-30-15 Hakataekimae, Hakata-ku, Fukuoka-sh, Fukuoka 11, JP)
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