Title:
COMPOUND WITH DIPYRROLOPYRIDINE STRUCTURE, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/247676
Kind Code:
A1
Abstract:
Disclosed in the present invention are a compound with a dipyrrolopyridine structure, and a preparation method therefor and the medical use thereof. The compound with the dipyrrolopyridine structure provided by the present invention has significant inhibitory activity on JAK family proteins, is an effective JAK inhibitor, and therefore has the prospect of being developed into a drug for inhibiting JAK so as to treat diseases.
Inventors:
YOU QIDONG (CN)
JIANG ZHENGYU (CN)
BAO QICHAO (CN)
MENG FANYING (CN)
GUO XIAOKE (CN)
XU XIAOLI (CN)
WANG LEI (CN)
SUN HAO (CN)
XIANG QIQI (CN)
JIANG ZHENGYU (CN)
BAO QICHAO (CN)
MENG FANYING (CN)
GUO XIAOKE (CN)
XU XIAOLI (CN)
WANG LEI (CN)
SUN HAO (CN)
XIANG QIQI (CN)
Application Number:
PCT/CN2022/093052
Publication Date:
December 01, 2022
Filing Date:
May 16, 2022
Export Citation:
Assignee:
NANJING KANGYI BIOMEDICAL CENTER LP (CN)
International Classes:
C07D471/14; A61K31/437; A61K31/4375; A61P35/00; A61P37/00
Domestic Patent References:
| WO2018112382A1 | 2018-06-21 | |||
| WO2019239387A1 | 2019-12-19 | |||
| WO2010119875A1 | 2010-10-21 |
Foreign References:
| CN113292561A | 2021-08-24 |
Other References:
"Organic Synthesis", 31 August 2017, HEFEI UNIVERSITY OF TECHNOLOGY PRESS, CN, ISBN: 9787565035180, article SHI, JINTAO: "8.2 Resolution of Optical Isomers", pages: 144 - 149, XP009542713
LEONARD, K.A. ET AL.: "Discovery of a Gut-Restricted JAK Inhibitor for the Treatment of Inflammatory Bowel Disease", JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, no. 6, 5 March 2020 (2020-03-05), XP055711298, DOI: 10.1021/acs.jmedchem.9b01439
LEONARD, K.A. ET AL.: "Discovery of a Gut-Restricted JAK Inhibitor for the Treatment of Inflammatory Bowel Disease", JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, no. 6, 5 March 2020 (2020-03-05), XP055711298, DOI: 10.1021/acs.jmedchem.9b01439
Attorney, Agent or Firm:
NANJING SUGAO PATENT AND TRADEMARK FIRM (ORDINARY PARTNERSHIP) (CN)
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