COMPOUND WITH INHIBITORY ACTIVITY AGAINST SIGMA2 AND 5HT2A AND USE

Title:

COMPOUND WITH INHIBITORY ACTIVITY AGAINST SIGMA2 AND 5HT2A AND USE

Document Type and Number:

WIPO Patent Application WO/2024/067304

Kind Code:

A1

Abstract:

The present invention provides a compound with inhibitory activity against Sigma2 and 5HT2A. The compound can be used as a dual-target inhibitor of Sigma2 and 5HT2A for the treatment of a related disease mediated by Sigma2 receptor activity, the treatment of a related disease mediated by 5HT2A receptor activity, and the treatment of a related disease mediated jointly by Sigma2 receptor activity and 5HT2A receptor activity, such as negative symptoms of schizophrenia.

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Inventors:

XING HONGTAO (CN)

Application Number:

PCT/CN2023/120119

Publication Date:

April 04, 2024

Filing Date:

September 20, 2023

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Assignee:

HAN YUAN MEDI PHARMA CO LTD (CN)

International Classes:

C07D211/58; A61K31/40; A61K31/445; A61K31/4468; A61P25/00; A61P25/18; C07D207/09; C07D211/26; C07D413/04; C07D451/06; C07D487/04

Attorney, Agent or Firm:

BEIJING YUNJIN IP LAW FIRM et al. (CN)

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