Title:
COMPOUNDS AS HER2 INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2024/027695
Kind Code:
A1
Abstract:
A class of compounds as HER2 inhibitors. Specifically, the present invention relates to compounds as shown in general formula (1), general formula (2) and general formula (3), a preparation method therefor, and the use of the compounds of general formula (1), general formula (2) and general formula (3), and isomers, crystal forms, pharmaceutically acceptable salts, hydrates or solvates thereof as HER2 inhibitors. The compounds and the isomers, crystal forms, pharmaceutically acceptable salts, hydrates or solvates thereof can be used in the preparation of drugs for treating or preventing diseases related to an HER2 protein.
Inventors:
XIE YULI (CN)
WU YINGMING (CN)
QIAN LIHUI (CN)
WU YINGMING (CN)
QIAN LIHUI (CN)
Application Number:
PCT/CN2023/110515
Publication Date:
February 08, 2024
Filing Date:
August 01, 2023
Export Citation:
Assignee:
WIGEN BIOMEDICINE TECH SHANGHAI CO LTD (CN)
International Classes:
C07D487/04; A61K31/519; A61P35/00; C07D519/00
Domestic Patent References:
| WO2021213800A1 | 2021-10-28 | |||
| WO2021156180A1 | 2021-08-12 | |||
| WO2021231400A1 | 2021-11-18 | |||
| WO2022221227A1 | 2022-10-20 | |||
| WO2022170043A1 | 2022-08-11 |
Foreign References:
| CN104513229A | 2015-04-15 | |||
| CN101356171A | 2009-01-28 | |||
| CN107141293A | 2017-09-08 | |||
| TW202309055A | 2023-03-01 |
Other References:
WILDING BIRGIT, SCHARN DIRK, BÖSE DIETRICH, BAUM ANKE, SANTORO VALERIA, CHETTA PAOLO, SCHNITZER RENATE, BOTESTEANU DANA A., REISER: "Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling", NATURE CANCER, vol. 3, no. 7, 1 July 2022 (2022-07-01), pages 821 - 836, XP093136173, ISSN: 2662-1347, DOI: 10.1038/s43018-022-00412-y
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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