Title:
COMPOUNDS AS INHIBITORS OF SODIUM CHANNELS
Document Type and Number:
WIPO Patent Application WO/2017/210371
Kind Code:
A3
Abstract:
Methods and small molecule compounds for inhibition of sodium channels are provided. One example of a class of compounds that may be used is represented by the compound of Formula (I) or a pharmaceutically acceptable salt, N-oxide or solvate thereof, wherein A, B, D, R, R1, R'1, R2, R3, R4, R5, R6, R7, R8 are as described herein.
Inventors:
CASHMAN JOHN R (US)
RYAN DANIEL J (US)
OKOLOTOWICZ KARL (US)
RYAN DANIEL J (US)
OKOLOTOWICZ KARL (US)
Application Number:
PCT/US2017/035328
Publication Date:
January 25, 2018
Filing Date:
May 31, 2017
Export Citation:
Assignee:
HUMAN BIOMOLECULAR RES INSTITUTE (US)
International Classes:
C07C217/58; A61K31/4412; C07D213/63
Foreign References:
| US8012901B1 | 2011-09-06 | |||
| US6300368B1 | 2001-10-09 | |||
| US20030073724A1 | 2003-04-17 |
Other References:
FRANCHINI, C. ET AL.: "Optically Active Mexiletine Analogues as Stereoselective Blockers of Voltage-Gated Na+ Channels", JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, no. 24, 2003, pages 5238 - 5248, XP055454588
HUANG, K. ET AL.: "Spiroborate Ester-Mediated Asymmetric Synthesis of beta-Hydroxy Ethers and Its Conversion to Highly Enantiopure beta-Amino Ethers", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 74, no. 11, 2009, pages 4195 - 4202, XP055454590
HUANG, K. ET AL.: "Spiroborate Ester-Mediated Asymmetric Synthesis of beta-Hydroxy Ethers and Its Conversion to Highly Enantiopure beta-Amino Ethers", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 74, no. 11, 2009, pages 4195 - 4202, XP055454590
Attorney, Agent or Firm:
CASTELLINO, Angelo (US)
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