Title:
COMPOUNDS AS MLKL INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2024/050825
Kind Code:
A1
Abstract:
A substituted cyclic compound as represented by formula (I) and having a selective inhibitory effect on MLKL, or a pharmaceutically acceptable salt, a stereoisomer, a solvate or a prodrug thereof, a pharmaceutical composition containing the compound and an application thereof in preparation of MLKL inhibitors.
Inventors:
ZHANG ZHIYUAN (CN)
CUI BO (CN)
YAN BO (CN)
CUI BO (CN)
YAN BO (CN)
Application Number:
PCT/CN2022/118169
Publication Date:
March 14, 2024
Filing Date:
September 09, 2022
Export Citation:
Assignee:
NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING (CN)
International Classes:
C07D239/12; A61K31/505; A61P25/28; A61P29/00; C07D239/36; C07D413/02
Domestic Patent References:
| WO2019242576A1 | 2019-12-26 | |||
| WO2018157800A1 | 2018-09-07 | |||
| WO2021031893A1 | 2021-02-25 | |||
| WO2018192416A1 | 2018-10-25 | |||
| WO2005021548A2 | 2005-03-10 |
Foreign References:
| US20190381052A1 | 2019-12-19 | |||
| CN110573509A | 2019-12-13 |
Attorney, Agent or Firm:
MERITS IP LTD. (CN)
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