Title:
COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF NUCLEIC ACID-BASED THERAPEUTICS AND METHODS THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/054669
Kind Code:
A3
Abstract:
The present disclosure provides compounds according to Formula I, II, III, IV, V, VI, VII, VIII, IX, X, XI, XII, XIII, and XIV used as a component of lipid nanoparticle compositions for the delivery of a biological and/or therapeutic agent. The present disclosure also provides novel, stable lipid nanoparticle compositions comprising one or more biological and/or therapeutic agents, methods of making the lipid nanoparticle compositions, and methods of delivering the lipid nanoparticle composition.
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Inventors:
XU XIAN (US)
CROVAK ROBERT (US)
WU HUABIN (US)
YUE ZHENG (US)
LIU FANG (US)
CROVAK ROBERT (US)
WU HUABIN (US)
YUE ZHENG (US)
LIU FANG (US)
Application Number:
PCT/US2023/032359
Publication Date:
April 18, 2024
Filing Date:
September 08, 2023
Export Citation:
Assignee:
NANOTECH PHARMA INC (US)
International Classes:
A61K31/7088; A61K48/00; A61K31/7115
Domestic Patent References:
| WO2017049245A2 | 2017-03-23 |
Foreign References:
| CN107954906A | 2018-04-24 | |||
| US3340299A | 1967-09-05 |
Other References:
DATABASE Compound 5 December 2007 (2007-12-05), PUBCHEM: "N,N,N',N'-tetrakis(2-methylpropyl)octane-1,8-diamine C24H52N2 ", XP093164243, Database accession no. CID 21291180
DATABASE Compound summary 9 February 2007 (2007-02-09), ANONYMOUS: "N,N-dimethyl-N',N'-bis(2-methylpropyl)ethane-1,2-diamine | C12H28N2 ", XP093164246, Database accession no. CID 15495302
DATABASE Compound summary 9 February 2007 (2007-02-09), ANONYMOUS: "N,N-dimethyl-N',N'-bis(2-methylpropyl)ethane-1,2-diamine | C12H28N2 ", XP093164246, Database accession no. CID 15495302
Attorney, Agent or Firm:
LIU, Wansheng Jerry et al. (US)
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