Title:
COMPOUNDS, COMPOSITIONS, AND METHODS FOR REDUCING PRODUCTION OF TRIMETHYLAMINE
Document Type and Number:
WIPO Patent Application WO/2024/011238
Kind Code:
A3
Abstract:
Provided herein are substituted quaternary amine salt compounds and compositions thereof for inhibiting production of trimethylamine (TMA), as well as inhibiting the conversion of choline to trimethylamine, and such compounds, and compositions thereof, utilized fortreating for example, kidney disease, diabetes and cardiovascular disease, disorders that are associated with inhibiting the conversion of choline to trimethylamine.
Inventors:
HAZEN STANLEY L (US)
ANDERSON JAMES (US)
ANDERSON JAMES (US)
Application Number:
PCT/US2023/069803
Publication Date:
May 16, 2024
Filing Date:
July 07, 2023
Export Citation:
Assignee:
CLEVELAND CLINIC FOUND (US)
International Classes:
A61K31/14; C07C69/52; C07C271/08; C07C309/03; C07C311/03; C07C311/08
Attorney, Agent or Firm:
REYNOLDS, Anne, M. (US)
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