Title:
COMPOUNDS, COMPOSITONS AND METHODS RELATED TO ANTIMICROBIAL APPLICATIONS
Document Type and Number:
WIPO Patent Application WO/2018/042367
Kind Code:
A3
Abstract:
The present disclosure is in the field of polymers and pharmaceuticals/antimicrobials. The disclosure provides compounds based on SNAP (synthetic novel antimicrobial polymer) technology, compositions and methods of managing microbial infections including surgical site infections (SSIs). The present compounds are used as a management/therapeutic strategy to target microbial infections and have advantages including excellent antimicrobial potency, biofilm disruption ability, broad spectrum activity against various organisms covering both gram negative and gram positive bacteria as well as fungal pathogens, and low toxicity profile to ensure a healthy therapeutic window for use in humans.
Inventors:
GHOSH SUMANA (IN)
SINHA MAU (IN)
BHATTACHARYYA ANAMIKA (IN)
SADHASIVAM SURESH (IN)
GHOSH SHAMIK (IN)
SAMANTA RITWIK (IN)
TANDON NUPUR (IN)
SINHA MAU (IN)
BHATTACHARYYA ANAMIKA (IN)
SADHASIVAM SURESH (IN)
GHOSH SHAMIK (IN)
SAMANTA RITWIK (IN)
TANDON NUPUR (IN)
Application Number:
PCT/IB2017/055245
Publication Date:
April 12, 2018
Filing Date:
August 31, 2017
Export Citation:
Assignee:
VYOME BIOSCIENCES PVT LTD (IN)
International Classes:
C08G73/02; C08G18/00; C08G63/00
Domestic Patent References:
| WO2012151554A1 | 2012-11-08 | |||
| WO2005016994A1 | 2005-02-24 | |||
| WO2017017631A2 | 2017-02-02 |
Foreign References:
| EP1551903A1 | 2005-07-13 |
Other References:
HUI WANG ET AL: "Structural Exploration of Phantom Oligoguanidine from Asymmetric Diamine and Guanidine Hydrochloride", MACROMOLECULAR CHEMISTRY AND PHYSICS., vol. 217, no. 16, 9 June 2016 (2016-06-09), DE, pages 1834 - 1841, XP055434961, ISSN: 1022-1352, DOI: 10.1002/macp.201600154
MINBIOLE KEVIN P C ET AL: "From antimicrobial activity to mechanism of resistance: the multifaceted role of simple quaternary ammonium compounds in bacterial eradication", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 72, no. 25, 12 January 2016 (2016-01-12), pages 3559 - 3566, XP029550390, ISSN: 0040-4020, DOI: 10.1016/J.TET.2016.01.014
BIKASH DEBNATH ET AL: "Small Molecule Inhibitors of CXCR4", THERANOSTICS, vol. 3, no. 1, 1 January 2013 (2013-01-01), AU, pages 47 - 75, XP055391478, ISSN: 1838-7640, DOI: 10.7150/thno.5376
MINBIOLE KEVIN P C ET AL: "From antimicrobial activity to mechanism of resistance: the multifaceted role of simple quaternary ammonium compounds in bacterial eradication", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 72, no. 25, 12 January 2016 (2016-01-12), pages 3559 - 3566, XP029550390, ISSN: 0040-4020, DOI: 10.1016/J.TET.2016.01.014
BIKASH DEBNATH ET AL: "Small Molecule Inhibitors of CXCR4", THERANOSTICS, vol. 3, no. 1, 1 January 2013 (2013-01-01), AU, pages 47 - 75, XP055391478, ISSN: 1838-7640, DOI: 10.7150/thno.5376
Attorney, Agent or Firm:
J, VIKAS et al. (IN)
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