Title:
COMPOUNDS HAVING A FUSED, BICYCLIC MOIETY FOR BINDING TO THE MINOR GROOVE OF DSDNA
Document Type and Number:
WIPO Patent Application WO2004099131
Kind Code:
A3
Abstract:
The present invention is directed to the means by which to alter the binding affinity and/or specificity of a compound with a sequence of DNA in the minor groove of a double-strand thereof. More particularly, the present invention is directed to a synthetic and/or non-naturally occurring compound (e.g., an analog of a polyamide oligomer or polymer) which contains at least one hydrogen bond donor moiety and at least one hydrogen bond acceptor moiety, wherein the latter moiety or "building block" has a fused, bicyclic structure which is heteroaromatic, said structure having a heteroatom therein which acts as a hydrogen bond acceptor to bind guanine in the minor groove of the dsDNA sequence, and which is incapable of forming a tautomer. In one particular embodiment of the synthetic and/or non-naturally occurring compound, the fused, bicyclic structure occupies an initial or first terminal position within the compound.
Inventors:
PHILLION DENNIS P (US)
BASHKIN JAMES K (US)
BASHKIN JAMES K (US)
Application Number:
PCT/US2004/013285
Publication Date:
February 17, 2005
Filing Date:
April 29, 2004
Export Citation:
Assignee:
PHARMACIA CORP (US)
PHILLION DENNIS P (US)
BASHKIN JAMES K (US)
PHILLION DENNIS P (US)
BASHKIN JAMES K (US)
International Classes:
C07D235/04; C07D401/00; C07D403/02; C07H19/04; C07H21/04; C12Q1/68; C07D; (IPC1-7): C07H19/04; C07D401/00; C07D235/04; C07D403/02
Domestic Patent References:
| WO2002101073A2 | 2002-12-19 |
Foreign References:
| US20020123635A1 | 2002-09-05 | |||
| US5807874A | 1998-09-15 |
Other References:
LOMBARDY R.L. ET AL.: "Synthesis and DNA interactions of benzimidazole dications which have activity against opportunistic infections", J. MED. CHEM., vol. 39, no. 7, 1996, pages 1452 - 1462, XP001020472
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