Title:
COMPOUNDS HAVING RORγt INHIBITORY EFFECTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
Document Type and Number:
WIPO Patent Application WO/2017/010399
Kind Code:
A1
Abstract:
Provided are compounds having RORγt inhibitory effects represented by formula (I). Compounds represented by formula (I) (wherein L represents -NR1ACO-, -SO2- or the like, A represents a substituted or unsubstituted aromatic carbocyclic group or the like, R1, R2, R3a, R4a, R3b and R4b represent hydrogen or substituted or unsubstituted alkyl or the like, m is from 0 to 2, n is 0 or 1, ring B represents an aromatic carbocyclic ring, an aromatic heterocyclic ring, etc., R1A represents hydrogen, etc., E represents SO2R10A, etc., R10A represents substituted or unsubstituted alkyl, etc., X represents =CR9- or =N-, R5 and R8 represent halogen, hydroxy, etc., R9 represents hydrogen, halogen, hydroxy, etc., R6 and R7 represent hydrogen, halogen, substituted or unsubstituted alkyl, etc., p is from 0 to 4 and q is from 0 to 3) or pharmaceutically acceptable salts thereof.
More Like This:
| JP3190431 | KETONE DERIVATIVE |
| WO/1999/001423 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS |
Inventors:
TAKIYAMA KEI (JP)
OHDAN MASAHIDE (JP)
SASAKI YOSHIKAZU (JP)
KIDA SHIRO (JP)
TACHIBANA YUKI (JP)
HATA KAYOKO (JP)
KATOU MANABU (JP)
OHDAN MASAHIDE (JP)
SASAKI YOSHIKAZU (JP)
KIDA SHIRO (JP)
TACHIBANA YUKI (JP)
HATA KAYOKO (JP)
KATOU MANABU (JP)
Application Number:
PCT/JP2016/070151
Publication Date:
January 19, 2017
Filing Date:
July 07, 2016
Export Citation:
Assignee:
SHIONOGI & CO (JP)
International Classes:
C07C317/28; A61K31/167; A61K31/343; A61K31/397; A61K31/403; A61K31/4168; A61K31/421; A61K31/426; A61K31/44; A61K31/445; A61K31/5375; A61P1/04; A61P17/06; A61P19/02; A61P25/00; A61P29/00; A61P37/06; C07C317/30; C07C317/44; C07C317/46; C07D205/04; C07D205/12; C07D207/12; C07D209/04; C07D209/08; C07D209/34; C07D209/44; C07D209/46; C07D211/38; C07D211/46; C07D211/48; C07D213/71; C07D213/74; C07D213/75; C07D213/84; C07D215/08; C07D231/18; C07D231/56; C07D233/84; C07D233/88; C07D235/06; C07D235/14; C07D235/26; C07D237/18; C07D237/20; C07D241/20; C07D263/48; C07D263/56; C07D263/58; C07D265/36; C07D271/06; C07D271/10; C07D277/46; C07D277/64; C07D277/68; C07D295/12; C07D295/182; C07D295/22; C07D305/08; C07D307/78; C07D309/14; C07D319/18; C07D417/06; C07D471/04; C07D491/107; C07D498/04; C07D513/04
Domestic Patent References:
| WO2015082533A1 | 2015-06-11 | |||
| WO2015083130A1 | 2015-06-11 | |||
| WO2009010478A2 | 2009-01-22 | |||
| WO2015145371A1 | 2015-10-01 | |||
| WO2015116904A1 | 2015-08-06 |
Other References:
YANG T ET AL: "Discovery of Tertiary Amine and Indole Derivatives as Potent ROR-gamma-t Inverse Agonists", ACS MEDICINAL CHEMISTRY LETTERS, vol. 5, no. 1, 2014, pages 65 - 68, XP002730929
Attorney, Agent or Firm:
YAMAUCHI, Hideaki et al. (JP)
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