Title:
Compounds having selective cyrochrome P450RA-1 or selective cytochrome P450RA-2 inhibitory activity and methods of obtaining the same
Document Type and Number:
WIPO Patent Application WO2005058798
Kind Code:
A3
Abstract:
Compounds of formulas 1 through 17 provided in the specification specifically or selectively inhibit either the cytochrome P450RAI-1 enzyme or the cytochrome P450RAI-2 enzyme.
Inventors:
VASUDEVAN JAYASREE (US)
WANG LIMING (US)
LIU XIAOXIA (US)
TSANG KOWK YIN (US)
LI LING (US)
TAKEUCHI JANET A (US)
VU THONG (US)
BEARD RICHARD L (US)
BHAT SIMITA (US)
VULIGONDA VIDYASAGAR (US)
CHADRARATNA ROSHANTA A (US)
WANG LIMING (US)
LIU XIAOXIA (US)
TSANG KOWK YIN (US)
LI LING (US)
TAKEUCHI JANET A (US)
VU THONG (US)
BEARD RICHARD L (US)
BHAT SIMITA (US)
VULIGONDA VIDYASAGAR (US)
CHADRARATNA ROSHANTA A (US)
Application Number:
PCT/US2004/042897
Publication Date:
February 16, 2006
Filing Date:
December 17, 2004
Export Citation:
Assignee:
ALLERGAN INC (US)
VASUDEVAN JAYASREE (US)
WANG LIMING (US)
LIU XIAOXIA (US)
TSANG KOWK YIN (US)
LI LING (US)
TAKEUCHI JANET A (US)
VU THONG (US)
BEARD RICHARD L (US)
BHAT SMITA (US)
VULIGONDA VIDYASAGAR (US)
CHADRARATNA ROSHANTA A (US)
VASUDEVAN JAYASREE (US)
WANG LIMING (US)
LIU XIAOXIA (US)
TSANG KOWK YIN (US)
LI LING (US)
TAKEUCHI JANET A (US)
VU THONG (US)
BEARD RICHARD L (US)
BHAT SMITA (US)
VULIGONDA VIDYASAGAR (US)
CHADRARATNA ROSHANTA A (US)
International Classes:
C07C57/42; C07C59/64; C07C59/86; C07C69/18; C07C69/73; C07C69/753; C07C69/76; C07C229/34; C07C229/38; C07C229/46; C07C229/50; C07C275/42; C07D311/58; C07D311/64; C07D311/96; (IPC1-7): C07D311/96; C07D311/64; C07D311/58; C07C59/64; C07C299/46; C07C59/86; C07C229/34; C07C69/753; C07C57/42; C07C69/18; C07C275/42; C07C229/38; C07C69/76
Foreign References:
| US6252090B1 | 2001-06-26 | |||
| US4326055A | 1982-04-20 | |||
| JPS58121242A | 1983-07-19 | |||
| US5349105A | 1994-09-20 | |||
| GB1277227A | 1972-06-07 |
Other References:
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CASTRO C E ET AL: "Copper(I) substitutions. Scope and mechanism of cuprous acetylide substitutions", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 91, no. 23, 5 November 1969 (1969-11-05), pages 6464 - 6470, XP002326252
ASAO N ET AL: "Pi-pi chelation controlled chemoselective conjugate addition of lithium dimethylcuprate", TETRAHEDRON LETTERS, vol. 44, no. 9, 24 February 2002 (2002-02-24), pages 1803 - 1805, XP004408806
COSTA A ET AL: "P2-Et-mediated deprotonation of ortho-halobenzyl sulfones: synthetic applications as zwitterionic synthons", SYNLETT, vol. 12, 2001, pages 1881 - 1884, XP001084388
HAMON D P G ET AL: "Enantioselective syntheses of 2-arylpropanoic acid non-steroidal anti-inflammatory drugs and related compounds", TETRAHEDRON, vol. 51, no. 46, 13 November 1995 (1995-11-13), pages 12645 - 12660, XP004104649
BOUCHAIN G ET AL: "Development of potential antitumor agents. Synthesis and biological evaluation of a new set of sulfonamide derivatives as histone deacetylase inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, no. 5, 27 February 2003 (2003-02-27), pages 820 - 830, XP002292252
XIN Z ET AL: "A practical and efficient intramolecular Michael addition of ureas to alpha,beta-unsaturated esters", TETRAHEDRON LETTERS, vol. 41, no. 8, February 2000 (2000-02-01), pages 1147 - 1150, XP004188577
NAKAO K ET AL: "Qualitative structure-activity analyses of novel hydroxyphenylurea derivatives as antioxidants", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 6, no. 6, 1998, pages 849 - 868, XP002309788
KWON B-M ET AL: "Synthesis and biological activity of cinnamaldehydes as angiogenesis inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 7, no. 19, 7 October 1997 (1997-10-07), pages 2473 - 2476, XP004136467
KONEK F VON ET AL: "Über einige neue Derivate der Paracumar- und Vanillinsäure", CHEMISCHE BERICHTE, vol. 51, 1918, pages 855 - 865, XP002326243
CASTRO C E ET AL: "Copper(I) substitutions. Scope and mechanism of cuprous acetylide substitutions", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 91, no. 23, 5 November 1969 (1969-11-05), pages 6464 - 6470, XP002326252
ASAO N ET AL: "Pi-pi chelation controlled chemoselective conjugate addition of lithium dimethylcuprate", TETRAHEDRON LETTERS, vol. 44, no. 9, 24 February 2002 (2002-02-24), pages 1803 - 1805, XP004408806
COSTA A ET AL: "P2-Et-mediated deprotonation of ortho-halobenzyl sulfones: synthetic applications as zwitterionic synthons", SYNLETT, vol. 12, 2001, pages 1881 - 1884, XP001084388
HAMON D P G ET AL: "Enantioselective syntheses of 2-arylpropanoic acid non-steroidal anti-inflammatory drugs and related compounds", TETRAHEDRON, vol. 51, no. 46, 13 November 1995 (1995-11-13), pages 12645 - 12660, XP004104649
BOUCHAIN G ET AL: "Development of potential antitumor agents. Synthesis and biological evaluation of a new set of sulfonamide derivatives as histone deacetylase inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, no. 5, 27 February 2003 (2003-02-27), pages 820 - 830, XP002292252
XIN Z ET AL: "A practical and efficient intramolecular Michael addition of ureas to alpha,beta-unsaturated esters", TETRAHEDRON LETTERS, vol. 41, no. 8, February 2000 (2000-02-01), pages 1147 - 1150, XP004188577
NAKAO K ET AL: "Qualitative structure-activity analyses of novel hydroxyphenylurea derivatives as antioxidants", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 6, no. 6, 1998, pages 849 - 868, XP002309788
KWON B-M ET AL: "Synthesis and biological activity of cinnamaldehydes as angiogenesis inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 7, no. 19, 7 October 1997 (1997-10-07), pages 2473 - 2476, XP004136467
KONEK F VON ET AL: "Über einige neue Derivate der Paracumar- und Vanillinsäure", CHEMISCHE BERICHTE, vol. 51, 1918, pages 855 - 865, XP002326243
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