Title:
COMPOUNDS FOR INHIBITING DISEASES AND PREPARING CELLS FOR TRANSPLANTATION
Document Type and Number:
WIPO Patent Application WO2001003680
Kind Code:
A3
Abstract:
Methods and compositions are provided for inhibiting, preventing and treating amyloid depositions, e.g. in pancreatic islets, wherein the amyloidotic deposits are islet amyloid polypeptide (IAPP)-associated amyloid deposition or deposits. Accordingly, the compositions and method of the invention are useful for inhibiting diabetes. The invention also provides a process for the preparation of cells suitable for transplantation into a mammal, which cells are capable of forming fibrils, said process comprising contacting the cells with an inhibitor of fibril formation. In particular the process prepares cells for use in a method of treating diabetes. Also provided are a culture medium comprising the inhibitor more particularly selected from the group consisting of 3-(3-hydroxy-1-propy)amino-1-propanesulfonic acid; DL-2-amino-5-phosphovaleric acid; 4-Phenyl-1-(3'-sulfopropyl)-1,2,3,6-tetrahydropyridine, cyclohexylsulfamic acid, O-phospho-L-serine, hexafluoroglutaric acid, 8-methoxyquinoline-5-sulfonic acid, 3-amino-2hydroxy-1-propanesulfonic acid, and 3-dimethylamino-1-propanesulfonic acid and 1,2,3,4-tetrahydroisoquinoleine.
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Inventors:
CLARK ANNE (GB)
FRASER PAUL (CA)
VERCHERE BRUCE (CA)
GUPTA AJAY (CA)
MIGNEAULT DAVID (CA)
SZAREK WALTER (CA)
WEAVER DONALD (CA)
FRASER PAUL (CA)
VERCHERE BRUCE (CA)
GUPTA AJAY (CA)
MIGNEAULT DAVID (CA)
SZAREK WALTER (CA)
WEAVER DONALD (CA)
Application Number:
PCT/GB2000/002623
Publication Date:
July 11, 2002
Filing Date:
July 07, 2000
Export Citation:
Assignee:
ISIS INNOVATION (GB)
NEUROCHEM INC (CA)
UNIV KINGSTON (CA)
CLARK ANNE (GB)
FRASER PAUL (CA)
VERCHERE BRUCE (CA)
GUPTA AJAY (CA)
MIGNEAULT DAVID (CA)
SZAREK WALTER (CA)
WEAVER DONALD (CA)
NEUROCHEM INC (CA)
UNIV KINGSTON (CA)
CLARK ANNE (GB)
FRASER PAUL (CA)
VERCHERE BRUCE (CA)
GUPTA AJAY (CA)
MIGNEAULT DAVID (CA)
SZAREK WALTER (CA)
WEAVER DONALD (CA)
International Classes:
A61K31/00; A61K31/185; A61K31/194; A61K31/44; A61K31/47; A61K31/472; A61P3/00; A61P25/00; C07K14/47; (IPC1-7): A61K31/145; A61K31/445; A61K31/451; A61K31/47; A61K31/472; A61K31/662; A61P3/00; A61P25/00
Domestic Patent References:
| WO1996037612A1 | 1996-11-28 | |||
| WO1994022437A2 | 1994-10-13 | |||
| WO1996028187A1 | 1996-09-19 | |||
| WO1994027602A1 | 1994-12-08 | |||
| WO1993003714A2 | 1993-03-04 | |||
| WO1998011923A1 | 1998-03-26 | |||
| WO2000071101A2 | 2000-11-30 | |||
| WO2000064420A2 | 2000-11-02 | |||
| WO1999040909A1 | 1999-08-19 |
Other References:
"USE OF METABOTROPIC AGONISTS IN PROGRESSIVE NEURODEGENERATIVE DISEASES", EXPERT OPINION ON THERAPEUTIC PATENTS, ASHLEY PUBLICATIONS, GB, vol. 5, no. 5, 1995, pages 491 - 493, XP001012270, ISSN: 1354-3776
SCHWARCZ R. ET AL: "Excitatory aminoacid antagonists provide a therapeutic approach to neurological disorders.", LANCET, (1985) 2/8447 (140-143). CODEN: LANCAO, XP001030857
COPANI A ET AL: "ACTIVATION OF METABOTROPIC GLUTAMATE RECEPTORS PROTECTS CULTURED NEURONS AGAINST APOPTOSIS INDUCED BY beta-AMYLOID PEPTIDE", MOLECULAR PHARMACOLOGY, BALTIMORE, MD, US, vol. 5, no. 47, 1995, pages 890 - 897, XP002079923, ISSN: 0026-895X
HUTCHINGS R ET AL: "The effect of excitotoxin antagonists on ibotenic acid-induced alteration of APP mRNA hippocampal expression.", JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 47, no. 12B, 1995, British Pharmaceutical Conference 1995: Science Proceedings of the 132nd Meeting;Warwick, England, UK; September 15-18, 1995, pages 1131, XP002079922, ISSN: 0022-3573
PACHE D M ET AL: "EFFECT OF SELECTIVE EXCITATORY AMINO ACID ANTAGONISTS ON EXCITOTOXIN-INDUCED CHANGES IN APP MRNA EXPRESSION", PHARMACOLOGY REVIEWS AND COMMUNICATIONS, GORDON AND BREACH, CH, vol. 10, no. 3, 1999, pages 205 - 212, XP001014486
SCHWARCZ R. ET AL: "Excitatory aminoacid antagonists provide a therapeutic approach to neurological disorders.", LANCET, (1985) 2/8447 (140-143). CODEN: LANCAO, XP001030857
COPANI A ET AL: "ACTIVATION OF METABOTROPIC GLUTAMATE RECEPTORS PROTECTS CULTURED NEURONS AGAINST APOPTOSIS INDUCED BY beta-AMYLOID PEPTIDE", MOLECULAR PHARMACOLOGY, BALTIMORE, MD, US, vol. 5, no. 47, 1995, pages 890 - 897, XP002079923, ISSN: 0026-895X
HUTCHINGS R ET AL: "The effect of excitotoxin antagonists on ibotenic acid-induced alteration of APP mRNA hippocampal expression.", JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 47, no. 12B, 1995, British Pharmaceutical Conference 1995: Science Proceedings of the 132nd Meeting;Warwick, England, UK; September 15-18, 1995, pages 1131, XP002079922, ISSN: 0022-3573
PACHE D M ET AL: "EFFECT OF SELECTIVE EXCITATORY AMINO ACID ANTAGONISTS ON EXCITOTOXIN-INDUCED CHANGES IN APP MRNA EXPRESSION", PHARMACOLOGY REVIEWS AND COMMUNICATIONS, GORDON AND BREACH, CH, vol. 10, no. 3, 1999, pages 205 - 212, XP001014486
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