Title:
COMPOUNDS INHIBITING TDG ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2020/224396
Kind Code:
A1
Abstract:
Provided in the present invention are a class of compounds inhibiting TDG activity. In particular, provided in the present invention is a compound as shown in formula I and which has a new structure. The small-molecule inhibitor of the present invention has an excellent inhibitory effect on TDG.
Inventors:
ZHU WEIXING (CN)
YANG SHENGLIAN (CN)
XU GUOLIANG (CN)
YANG SHENGLIAN (CN)
XU GUOLIANG (CN)
Application Number:
PCT/CN2020/084755
Publication Date:
November 12, 2020
Filing Date:
April 14, 2020
Export Citation:
Assignee:
EPITAS BIOSCIENCES SHANGHAI CO LTD (CN)
International Classes:
A61K31/357; C07D405/06; A61K31/397; A61K31/4025; A61K31/4035; A61K31/4155; A61K31/416; A61K31/427; A61K31/437; A61K31/4433; A61K31/453; A61K31/4725; A61K31/506; A61K31/538; A61K31/55; A61P35/00; C07D209/44; C07D319/18; C07D401/06; C07D405/12; C07D411/06; C07D413/06; C07D417/06; C07D471/04
Domestic Patent References:
| WO2008154207A1 | 2008-12-18 |
Foreign References:
| GB1364993A | 1974-08-29 | |||
| GB1398023A | 1975-06-18 | |||
| SU513699A1 | 1976-05-15 | |||
| US20090163545A1 | 2009-06-25 | |||
| DD66175A |
Other References:
STARYKH N T : "Pharmacological Characteristics of Certain Substances of the Benzodioxane and Amino Ketone Group", FARMAKOLOGIYA I TOKSIKOLOGIYA (MOSCOW), vol. 27, no. 1, 1 January 1964 (1964-01-01), RU , pages 546 - 550, XP009531388, ISSN: 0014-8318
BERTINI, V. ET AL.: "Synthesis of Tailor-made Copolymers Containing 1, 4-Benzodioxane Systems for pH Controlled Selective Flocculation of Mineral Dispersions", EUROPEAN POLYMER JOURNAL, vol. 24, no. 5, 31 December 1988 (1988-12-31), XP024052397, ISSN: 0014-3057, DOI: 20200603152019X
DATABASE REGISTRY 13 September 2002 (2002-09-13), ANONYMOUS: "1-Propanone, 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[3-(4-fluorophenyl)-3- hydroxy-1-pyrrolidinyl]- (CA INDEX NAME)", XP055860246, retrieved from STN Database accession no. 450356-27-1
DATABASE REGISTRY 18 June 2002 (2002-06-18), ANONYMOUS: "1-Butanone, 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-(3-phenyl-1- pyrrolidinyl)- (CA INDEX NAME)", XP055860248, retrieved from STN Database accession no. 431938-85-1
DATABASE REGISTRY 5 June 2002 (2002-06-05), ANONYMOUS: " 1-Propanone, 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-(1,3-dihydro-2H- isoindol-2-yl)- (CA INDEX NAME)", XP055860258, retrieved from STN Database accession no. 425653-35-6
DATABASE REGISTRY 6 June 2002 (2002-06-06), ANONYMOUS: "1-Propanone, 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-(3,4-dihydro-2(1H)- isoquinolinyl)- (CA INDEX NAME)", XP055860259, retrieved from STN Database accession no. 426234-50-6
DATABASE REGISTRY 29 April 2007 (2007-04-29), ANONYMOUS: " 1-Butanone, 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-(3,4-dihydro-2(1H)- isoquinolinyl)- (CA INDEX NAME)", XP055860264, retrieved from STN Database accession no. 933217-85-7
DATABASE REGISTRY 16 June 2009 (2009-06-16), ANONYMOUS: "1-Butanone, 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-(3-phenyl-1- pyrrolidinyl)-, hydriodide (1:1) (CA INDEX NAME)", XP055860267, retrieved from STN Database accession no. 1158317-48-6
DATABASE REGISTRY 16 June 2009 (2009-06-16), ANONYMOUS: "1-Butanone, 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-(3,4-dihydro-2(1H)- isoquinolinyl)-, hydrochloride (1:1) (CA INDEX NAME)", XP055860269, retrieved from STN Database accession no. 1158587-76-8
DATABASE REGISTRY 17 June 2009 (2009-06-17), ANONYMOUS: "1-Propanone, 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[3-(4-fluorophenyl)-3- hydroxy-1-pyrrolidinyl]-, hydrochloride (1:1) (CA INDEX NAME)", XP055860272, retrieved from STN Database accession no. 1158752-80-7
DATABASE REGISTRY 23 June 2004 (2004-06-23), ANONYMOUS: "1-Propanone, 3-(1,3-dihydro-2H-isoindol-2-yl)-1-(3,4-dimethoxyphenyl)- (CA INDEX NAME)", XP055860275, retrieved from STN Database accession no. 698336-98-0
DATABASE REGISTRY 5 September 2004 (2004-09-05), ANONYMOUS: "1-Propanone, 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-(1-pyrrolidinyl)- (CA INDEX NAME)", XP055860278, retrieved from STN Database accession no. 740018-68-2
DATABASE REGISTRY 5 June 2002 (2002-06-05), ANONYMOUS: "1-Propanone, 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-(2,3-dihydro-1H-indol1-yl)- (CA INDEX NAME)", XP055860280, retrieved from STN Database accession no. 425654-69-9
BERTINI, V. ET AL.: "Synthesis of Tailor-made Copolymers Containing 1, 4-Benzodioxane Systems for pH Controlled Selective Flocculation of Mineral Dispersions", EUROPEAN POLYMER JOURNAL, vol. 24, no. 5, 31 December 1988 (1988-12-31), XP024052397, ISSN: 0014-3057, DOI: 20200603152019X
DATABASE REGISTRY 13 September 2002 (2002-09-13), ANONYMOUS: "1-Propanone, 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[3-(4-fluorophenyl)-3- hydroxy-1-pyrrolidinyl]- (CA INDEX NAME)", XP055860246, retrieved from STN Database accession no. 450356-27-1
DATABASE REGISTRY 18 June 2002 (2002-06-18), ANONYMOUS: "1-Butanone, 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-(3-phenyl-1- pyrrolidinyl)- (CA INDEX NAME)", XP055860248, retrieved from STN Database accession no. 431938-85-1
DATABASE REGISTRY 5 June 2002 (2002-06-05), ANONYMOUS: " 1-Propanone, 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-(1,3-dihydro-2H- isoindol-2-yl)- (CA INDEX NAME)", XP055860258, retrieved from STN Database accession no. 425653-35-6
DATABASE REGISTRY 6 June 2002 (2002-06-06), ANONYMOUS: "1-Propanone, 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-(3,4-dihydro-2(1H)- isoquinolinyl)- (CA INDEX NAME)", XP055860259, retrieved from STN Database accession no. 426234-50-6
DATABASE REGISTRY 29 April 2007 (2007-04-29), ANONYMOUS: " 1-Butanone, 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-(3,4-dihydro-2(1H)- isoquinolinyl)- (CA INDEX NAME)", XP055860264, retrieved from STN Database accession no. 933217-85-7
DATABASE REGISTRY 16 June 2009 (2009-06-16), ANONYMOUS: "1-Butanone, 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-(3-phenyl-1- pyrrolidinyl)-, hydriodide (1:1) (CA INDEX NAME)", XP055860267, retrieved from STN Database accession no. 1158317-48-6
DATABASE REGISTRY 16 June 2009 (2009-06-16), ANONYMOUS: "1-Butanone, 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-(3,4-dihydro-2(1H)- isoquinolinyl)-, hydrochloride (1:1) (CA INDEX NAME)", XP055860269, retrieved from STN Database accession no. 1158587-76-8
DATABASE REGISTRY 17 June 2009 (2009-06-17), ANONYMOUS: "1-Propanone, 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[3-(4-fluorophenyl)-3- hydroxy-1-pyrrolidinyl]-, hydrochloride (1:1) (CA INDEX NAME)", XP055860272, retrieved from STN Database accession no. 1158752-80-7
DATABASE REGISTRY 23 June 2004 (2004-06-23), ANONYMOUS: "1-Propanone, 3-(1,3-dihydro-2H-isoindol-2-yl)-1-(3,4-dimethoxyphenyl)- (CA INDEX NAME)", XP055860275, retrieved from STN Database accession no. 698336-98-0
DATABASE REGISTRY 5 September 2004 (2004-09-05), ANONYMOUS: "1-Propanone, 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-(1-pyrrolidinyl)- (CA INDEX NAME)", XP055860278, retrieved from STN Database accession no. 740018-68-2
DATABASE REGISTRY 5 June 2002 (2002-06-05), ANONYMOUS: "1-Propanone, 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-(2,3-dihydro-1H-indol1-yl)- (CA INDEX NAME)", XP055860280, retrieved from STN Database accession no. 425654-69-9
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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