Title:
COMPOUNDS FOR THE INHIBITION OF CELLULAR PROLIFERATION
Document Type and Number:
WIPO Patent Application WO/2012/006068
Kind Code:
A3
Abstract:
Compositions and methods for inhibiting translation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, (4) disorders associated with viral infections, and/or (5) non-proliferative metabolic disorders such as type II diabetes where inhibition of translation initiation is beneficial using the compounds disclosed herein.
Inventors:
CHOREV MICHAEL (US)
AKTAS BERTAL HUSEYIN (US)
HALPERIN JOSE A (US)
WAGNER GERHARD (US)
AKTAS BERTAL HUSEYIN (US)
HALPERIN JOSE A (US)
WAGNER GERHARD (US)
Application Number:
PCT/US2011/042139
Publication Date:
May 10, 2013
Filing Date:
June 28, 2011
Export Citation:
Assignee:
HARVARD COLLEGE (US)
CHOREV MICHAEL (US)
AKTAS BERTAL HUSEYIN (US)
HALPERIN JOSE A (US)
WAGNER GERHARD (US)
CHOREV MICHAEL (US)
AKTAS BERTAL HUSEYIN (US)
HALPERIN JOSE A (US)
WAGNER GERHARD (US)
International Classes:
A61K31/33; A61K31/41; A61K31/50
Domestic Patent References:
| WO2007028999A1 | 2007-03-15 |
Other References:
LI ET AL.: "Prediction of the 3D Structure and dynamics of Human DP G-Protein Coupled Receptor bound to an agonist and an antagonist.", JACS, vol. 129, no. 35, 2007, pages 10720 - 10731, XP055102666
SHIRAISHI ET AL.: "Cyclooxyganase-2lProstaglandin D2/CRTH2 Pathway Mediates Double- Stranded RNA-Induced Enhancement of Allergic Airway Inflammation.", J IMMUNOL, vol. 180, 2008, pages 541 - 549, XP055105179
MOERKE ET AL.: "Small-MOlecule Inhibition of the Interaction between the Translation Initiation Factors eIF4E and elF4G.", CELL, vol. 128, 2007, pages 257 - 267, XP055043757
See also references of EP 2585453A4
SHIRAISHI ET AL.: "Cyclooxyganase-2lProstaglandin D2/CRTH2 Pathway Mediates Double- Stranded RNA-Induced Enhancement of Allergic Airway Inflammation.", J IMMUNOL, vol. 180, 2008, pages 541 - 549, XP055105179
MOERKE ET AL.: "Small-MOlecule Inhibition of the Interaction between the Translation Initiation Factors eIF4E and elF4G.", CELL, vol. 128, 2007, pages 257 - 267, XP055043757
See also references of EP 2585453A4
Attorney, Agent or Firm:
IWANICKI, John P. (28 State Street,Suite 180, Boston Massachusetts, US)
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