Title:
COMPOUNDS AND METHOD OF USE THEREOF FOR TREATING BACTERIAL DISEASES
Document Type and Number:
WIPO Patent Application WO/2023/104017
Kind Code:
A1
Abstract:
The present disclosure provides compounds that can inhibit the type III secretion system (TTSS) to decrease the pathogenesis of gram-negative bacteria. These compounds may have wide applications for treating bacteria diseases caused by gram-negative bacteria in a host species, including but not limited to, plants and animals. The present invention further relates to compositions that inhibit pathogenesis of gram-negative bacteria without killing the bacteria. Methods relating to preventing and/or treating infection of a host species by bacterial pathogens are also provided herein.
Inventors:
LEI XIAOGUANG (CN)
ZHOU JIAN-MIN (CN)
WANG HAIJUN (CN)
MIAO PEI (CN)
WANG WEI (CN)
ZHOU JIAN-MIN (CN)
WANG HAIJUN (CN)
MIAO PEI (CN)
WANG WEI (CN)
Application Number:
PCT/CN2022/136852
Publication Date:
June 15, 2023
Filing Date:
December 06, 2022
Export Citation:
Assignee:
UNIV BEIJING (CN)
INST GENETICS & DEVELOPMENTAL BIOLOGY CAS (CN)
INST GENETICS & DEVELOPMENTAL BIOLOGY CAS (CN)
International Classes:
C07C233/02; A01N33/02; A01N43/02; C07C231/00; C07C233/09; C07D307/26
Domestic Patent References:
| WO2013034621A1 | 2013-03-14 | |||
| WO2009156252A1 | 2009-12-30 | |||
| WO2020236718A1 | 2020-11-26 | |||
| WO2014082130A1 | 2014-06-05 |
Foreign References:
| US20180296395A1 | 2018-10-18 | |||
| US20110301078A1 | 2011-12-08 |
Other References:
SUN, LINHE; CHANG, YAJUN; HAN, SHIQUN; CUI, JIAN; LIU, XIAOJING: "Metabolomics Analysis of Bioactive Compounds in Culture Water Planting Floating Bed Water Dropwort in Different Development Stages", RESEARCH OF ENVIRONMENTAL SCIENCES, vol. 34, no. 8, 31 August 2021 (2021-08-31), pages 1860 - 1875, XP009546790, ISSN: 1001-6929, DOI: 10.13198/j.issn.1001-6929.2021.03.04
ZIESCHE LISA, WOLTER LAURA, WANG HUI, BRINKHOFF THORSTEN, POHLNER MARION, ENGELEN BERT, WAGNER-DÖBLER IRENE, SCHULZ STEFAN: "An Unprecedented Medium-Chain Diunsaturated N-acylhomoserine Lactone from Marine Roseobacter Group Bacteria", MARINE DRUGS, vol. 17, no. 1, pages 20, XP093070332, DOI: 10.3390/md17010020
ZIESCHE LISA, WOLTER LAURA, WANG HUI, BRINKHOFF THORSTEN, POHLNER MARION, ENGELEN BERT, WAGNER-DÖBLER IRENE, SCHULZ STEFAN: "An Unprecedented Medium-Chain Diunsaturated N-acylhomoserine Lactone from Marine Roseobacter Group Bacteria", MARINE DRUGS, vol. 17, no. 1, pages 20, XP093070332, DOI: 10.3390/md17010020
Attorney, Agent or Firm:
BEIJING CAIHE LAW FIRM (CN)
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