COMPOUNDS AND METHODS FOR IDENTIFYING COMPOUNDS WHICH INHIBIT A NEW CLASS OF ASPARTYL PROTEASES

Title:

COMPOUNDS AND METHODS FOR IDENTIFYING COMPOUNDS WHICH INHIBIT A NEW CLASS OF ASPARTYL PROTEASES

Document Type and Number:

WIPO Patent Application WO2001004277

Kind Code:

A9

Abstract:

Compounds and methods for designing and identifying compounds which inhibit TFPP-like aspartyl protease enzymes by targeting the aspartic acid residues of the active site or mimicking peptides corresponding to the region surrounding the substrate's cleavage site are provided. Agents identified as inhibitors of TFPP-like aspartyl proteases such as type 4 prepilin peptidases are expected to be useful as anti-bacterial agents and in inhibiting development of drug resistant strains of bacteria.

Inventors:

TAYLOR RONALD K (US)
LAPOINTE CHRISTIAN F (US)

Application Number:

PCT/US2000/018775

Publication Date:

July 11, 2002

Filing Date:

July 11, 2000

Export Citation:

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Assignee:

DARTMOUTH COLLEGE (US)
TAYLOR RONALD K (US)
LAPOINTE CHRISTIAN F (US)

International Classes:

C08K3/34; C08K7/00; C08K9/04; C12N9/52; (IPC1-7): C12N9/48; A61K38/00; C07K1/00; C12Q1/37

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