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Title:
COMPOUNDS AND METHODS FOR MODULATING APOLIPOPROTEIN C-III EXPRESSION FOR IMPROVING A DIABETIC PROFILE
Document Type and Number:
WIPO Patent Application WO/2014/205449
Kind Code:
A3
Abstract:
Provided herein are improved compounds, compositions and associated methods for reducing expression of ApoCIII mRNA and protein in a subject having, or at risk of having, diabetes. Also provided herein are compounds, compositions and associated methods improving peripheral insulin sensitivity, a lipid profile and a diabetes profile as well as reducing free fatty acids and intramyocellular triglyceride deposition.

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Inventors:
CROOKE ROSANNE M (US)
ALEXANDER VERONICA J (US)
Application Number:
PCT/US2014/043723
Publication Date:
April 23, 2015
Filing Date:
June 23, 2014
Export Citation:
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Assignee:
ISIS PHARMACEUTICALS INC (US)
International Classes:
C12N15/11; C07H21/04; C12N5/00
Domestic Patent References:
WO2012149495A12012-11-01
Foreign References:
US20110060030A12011-03-10
Other References:
SAMUEL ET AL.: "Mechanisms for insulin resistance: common threads and missing links.", CELL, vol. 148, no. 5, 2012, pages 852 - 871, XP028402801
Attorney, Agent or Firm:
GRANT, Bruce, D. et al. (2714 Loker Ave W Suite 11, Carlsbad CA, US)
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