Title:
COMPOUNDS AND METHODS FOR TREATING NEOPLASIA
Document Type and Number:
WIPO Patent Application WO/2011/029639
Kind Code:
A3
Abstract:
The invention features compounds, pharmaceutical compositions and methods useful for the treatment of neoplasia. In particular embodiments, the compounds of the invention are useful for the treatment of multidrug resistant neoplasia.
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Inventors:
ALEVIZOPOULOS KONSTANTINOS (GR)
CALOGEROPOULOU THEODORA (GR)
STOURNARAS CHRISTOS (GR)
CALOGEROPOULOU THEODORA (GR)
STOURNARAS CHRISTOS (GR)
Application Number:
PCT/EP2010/058842
Publication Date:
May 05, 2011
Filing Date:
June 22, 2010
Export Citation:
Assignee:
MEDEXIS S A (GR)
ALEVIZOPOULOS KONSTANTINOS (GR)
CALOGEROPOULOU THEODORA (GR)
STOURNARAS CHRISTOS (GR)
ALEVIZOPOULOS KONSTANTINOS (GR)
CALOGEROPOULOU THEODORA (GR)
STOURNARAS CHRISTOS (GR)
International Classes:
C07J41/00; A61K31/565; A61K31/58; A61P35/00; C07J43/00
Domestic Patent References:
| WO2009032321A2 | 2009-03-12 | |||
| WO2006029020A2 | 2006-03-16 |
Foreign References:
| US3968105A | 1976-07-06 | |||
| US3271426A | 1966-09-06 | |||
| US3816406A | 1974-06-11 | |||
| US3328387A | 1967-06-27 |
Other References:
JINDAL D P ET AL: "Synthesis and antineoplastic activity of 2-alkylaminoethyl derivatives of various steroidal oximes", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 38, no. 11-12, 1 November 2003 (2003-11-01), pages 1025 - 1034, XP004475848, ISSN: 0223-5234, DOI: DOI:10.1016/J.EJMECH.2003.09.002
VILLANI F J ET AL: "Oximino ethers: dialkylaminoalkyl derivatives.", JOURNAL OF PHARMACEUTICAL SCIENCES JAN 1969 LNKD- PUBMED:5765825, vol. 58, no. 1, January 1969 (1969-01-01), pages 138 - 140, XP002617510, ISSN: 0022-3549
HIRSCH A F ET AL: "Contragestational Agents. 1. Steroidal O-Aryloximes", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US, vol. 20, no. 12, 1 January 1977 (1977-01-01), pages 1546 - 1551, XP002275447, ISSN: 0022-2623, DOI: DOI:10.1021/JM00222A002
JOHANSSON S ET AL: "Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells", ANTI-CANCER DRUGS, LIPPINCOTT WILLIAMS & WILKINS, US; NL, vol. 12, 1 June 2001 (2001-06-01), pages 475 - 483, XP008055680, ISSN: 0959-4973, DOI: DOI:10.1097/00001813-200106000-00009
FARNSWORTH ET AL: "Na<+>,K<+>-ATPase: The actual androgen receptor of the prostate?", MEDICAL HYPOTHESES, EDEN PRESS, PENRITH, US, vol. 41, no. 4, 1 October 1993 (1993-10-01), pages 358 - 362, XP023026352, ISSN: 0306-9877, [retrieved on 19931001], DOI: DOI:10.1016/0306-9877(93)90084-4
VILLANI F J ET AL: "Oximino ethers: dialkylaminoalkyl derivatives.", JOURNAL OF PHARMACEUTICAL SCIENCES JAN 1969 LNKD- PUBMED:5765825, vol. 58, no. 1, January 1969 (1969-01-01), pages 138 - 140, XP002617510, ISSN: 0022-3549
HIRSCH A F ET AL: "Contragestational Agents. 1. Steroidal O-Aryloximes", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US, vol. 20, no. 12, 1 January 1977 (1977-01-01), pages 1546 - 1551, XP002275447, ISSN: 0022-2623, DOI: DOI:10.1021/JM00222A002
JOHANSSON S ET AL: "Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells", ANTI-CANCER DRUGS, LIPPINCOTT WILLIAMS & WILKINS, US; NL, vol. 12, 1 June 2001 (2001-06-01), pages 475 - 483, XP008055680, ISSN: 0959-4973, DOI: DOI:10.1097/00001813-200106000-00009
FARNSWORTH ET AL: "Na<+>,K<+>-ATPase: The actual androgen receptor of the prostate?", MEDICAL HYPOTHESES, EDEN PRESS, PENRITH, US, vol. 41, no. 4, 1 October 1993 (1993-10-01), pages 358 - 362, XP023026352, ISSN: 0306-9877, [retrieved on 19931001], DOI: DOI:10.1016/0306-9877(93)90084-4
Attorney, Agent or Firm:
PATENTANWÄLTE REITSTÖTTER KINZEBACH (München, DE)
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