COMPOUNDS FOR MODULATING ACTIVITY OF FXR AND USES THEREOF

Title:

COMPOUNDS FOR MODULATING ACTIVITY OF FXR AND USES THEREOF

Document Type and Number:

WIPO Patent Application WO/2021/108974

Kind Code:

A1

Abstract:

Provided are compounds of formula (I) and pharmaceutically acceptable salts, esters or stereoisomers thereof, which can be used for modulating the activity of FXR.

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Inventors:

YANG BAILING (CN)
GUDMUNDSSON KRISTJAN (CN)
DONG LIUYU (CN)
CHEN JAMES (CN)

Application Number:

PCT/CN2019/122595

Publication Date:

June 10, 2021

Filing Date:

December 03, 2019

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Assignee:

GANNEX PHARMA CO LTD (CN)

International Classes:

C07D417/12; A61K31/42; A61P1/16; A61P3/00; A61P3/04; A61P3/10

Domestic Patent References:

WO2009005998A1

2009-01-08

Foreign References:

US20170304270A1

2017-10-26

Other References:

AKWABI-AMEYAW, A. ; BASS, J.Y. ; CALDWELL, R.D. ; CARAVELLA, J.A. ; CHEN, L. ; CREECH, K.L. ; DEATON, D.N. ; MADAUSS, K.P. ; MARR,: "FXR agonist activity of conformationally constrained analogs of GW 4064", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, no. 16, 15 August 2009 (2009-08-15), pages 4733 - 4739, XP026419067, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2009.06.062

Attorney, Agent or Firm:

PANAWELL & PARTNERS, LLC (CN)

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