Title:
COMPOUNDS FOR MODULATING ACTIVITY OF FXR AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/077161
Kind Code:
A1
Abstract:
Provided is a Compound for modulating the activity of FXR having a structure of formula (I), a pharmaceutically acceptable salt, an ester or a stereoisomer thereof, wherein M, Q, T, W, Y and Z are independently selected from N and O, and at least one of M, Q, T, W, Y and Z is N.
Inventors:
YANG BAILING (CN)
KRISTJAN GUDMUNDSSON (CN)
DONG LIUYU (CN)
CHEN JAMES (CN)
KRISTJAN GUDMUNDSSON (CN)
DONG LIUYU (CN)
CHEN JAMES (CN)
Application Number:
PCT/CN2020/120372
Publication Date:
April 21, 2022
Filing Date:
October 12, 2020
Export Citation:
Assignee:
GANNEX PHARMA CO LTD (CN)
International Classes:
C07D413/14; A61K31/422; A61K31/47; A61P1/16; A61P3/00; A61P3/10
Domestic Patent References:
| WO2017189652A1 | 2017-11-02 |
Foreign References:
| CN101877966A | 2010-11-03 | |||
| CN107021957A | 2017-08-08 |
Other References:
ABEL, ULRICH ET AL.: "S ynthesis and pharmacological validation of a novel series of non- steroidal FXR agonists", JOURNAL OF BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 20, 19 June 2010 (2010-06-19), pages 4911 - 4917, XP027172649
Attorney, Agent or Firm:
PANAWELL & PARTNERS, LLC (CN)
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