Title:
Compounds, pharmaceutical compositions containing them and their medical use for the treatment or prevention of vascular diseases
Document Type and Number:
WIPO Patent Application WO/2024/005556
Kind Code:
A1
Abstract:
The present disclosure provides compounds capable of exhibiting effects similar to those of 2-Cys-peroxyredoxin (2-Cys-Prx) in the body with excellent pharmacological effects and reduced side effects such as reduced cytotoxicity, and pharmaceutical uses thereof. The compounds of the present disclosure and their pharmaceutically acceptable salts are useful for the treatment or prevention of vascular diseases, particularly ischemic coronary artery disease, arteriosclerosis, vascular restenosis, or pulmonary arterial hypertension. The compounds of the present invention and their pharmaceutically acceptable salts are particularly useful for the treatment or prevention of pulmonary arterial hypertension. The invention also provides methods of preparing the compounds of the present disclosure.
Inventors:
KANG SANG WON (KR)
LEE KYUNG JOO (KR)
KANG DONG HOON (KR)
JALANI HITESHKUMAR BHANUBHAI (IN)
LEE DOO JAE (KR)
JUNG SUNG HOON (KR)
LEE KYUNG JOO (KR)
KANG DONG HOON (KR)
JALANI HITESHKUMAR BHANUBHAI (IN)
LEE DOO JAE (KR)
JUNG SUNG HOON (KR)
Application Number:
PCT/KR2023/009076
Publication Date:
January 04, 2024
Filing Date:
June 28, 2023
Export Citation:
Assignee:
VASTHERA CO LTD (KR)
UNIV EWHA IND COLLABORATION (KR)
UNIV EWHA IND COLLABORATION (KR)
International Classes:
C07D513/08; A61K31/554; A61P9/00; A61P9/12; C07D513/18
Domestic Patent References:
| WO2014189343A1 | 2014-11-27 | |||
| WO2006066775A1 | 2006-06-29 |
Foreign References:
| CN114437114A | 2022-05-06 |
Other References:
WEI, W. ET AL.: "An antibacterial metabolite from Lasiodiplodia pseudotheobromae F2", PHYTOCHEMISTRY, vol. 100, 2014, pages 103 - 109, XP018519091
OLSSON, C. ET AL.: "Synthesis of Potent Cytotoxic Epidithiodiketopiperazines Designed for Derivatization", JOURNAL OF ORGANIC CHEMISTRY, vol. 85, no. 7, 2020, pages 4648 - 4662, XP055719354, DOI: 10.1021/acs.joc.9b03371
OLSSON, C. ET AL.: "Synthesis of Potent Cytotoxic Epidithiodiketopiperazines Designed for Derivatization", JOURNAL OF ORGANIC CHEMISTRY, vol. 85, no. 7, 2020, pages 4648 - 4662, XP055719354, DOI: 10.1021/acs.joc.9b03371
Attorney, Agent or Firm:
PHIL & ONZI INT'L PATENT & LAW FIRM (KR)
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