Title:
COMPOUNDS POSSESSING PTP1B INHIBITORY ACTIVITY, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/204018
Kind Code:
A1
Abstract:
Provided in the present invention are two compounds possessing PTP1B inhibitory activity, said compounds having structures represented by formula (1) or formula (2). Disclosed in the present invention are two hydroquinone-containing meroterpenoid compounds newly discovered from Ganoderma ahmadii Steyaret. Upon undergoing biological activity evaluation, it was discovered that this type of compound has significant PTP1B inhibitory activity, enhances insulin receptor sensitivity, and possesses application prospects for developing a medicine for diabetes.
Inventors:
ZHAO YOUXING (CN)
KONG FANDONG (CN)
MA QINGYUN (CN)
XIE QINGYI (CN)
YANG LI (CN)
GUO JIAOCEN (CN)
ZHOU LIMAN (CN)
DAI HAOFU (CN)
KONG FANDONG (CN)
MA QINGYUN (CN)
XIE QINGYI (CN)
YANG LI (CN)
GUO JIAOCEN (CN)
ZHOU LIMAN (CN)
DAI HAOFU (CN)
Application Number:
PCT/CN2021/083890
Publication Date:
October 14, 2021
Filing Date:
March 30, 2021
Export Citation:
Assignee:
INST TROPICAL BIOSCIENCE & BIOTECHNOLOGY CATAS (CN)
International Classes:
A61K31/216; C07C69/732; A61P3/10; C07C67/56; C07C67/58
Domestic Patent References:
| WO2019053159A1 | 2019-03-21 |
Foreign References:
| CN111302942A | 2020-06-19 | |||
| CN107163009A | 2017-09-15 | |||
| CN108892651A | 2018-11-27 | |||
| US20120094942A1 | 2012-04-19 | |||
| CN107056867A | 2017-08-18 | |||
| CN104873520A | 2015-09-02 |
Other References:
BAO KUN, CHEN PING;BI YUN-FENG;WANG JIA-NAN;FANG HONG-SHUAI;MIAO YU-QIANG: "Hypoglycemic Effect of Ganoderma Lucidum Active Component", CHINESE JOURNAL OF VETERINARY DRUG, ZHONGGUO SHOUYI YAOPIN JIANCHASUO, CN, vol. 49, no. 1, 31 December 2015 (2015-12-31), CN , pages 29 - 32, XP055855869, ISSN: 1002-1280
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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