Title:
COMPOUNDS REDUCING SAICAR SYNTHASE ACTIVITY, AND APPLICATIONS
Document Type and Number:
WIPO Patent Application WO/2018/059216
Kind Code:
A1
Abstract:
Disclosed are compounds reducing SAICAR synthase activity, and applications. On the basis of existing protein structure data and small molecule structure data, calculations and analysis are performed using software to screen and obtain compounds capable of effectively interfering with PAICS activity, reducing SAICAR synthesis, and ultimately reducing SAICAR accumulation, in order to achieve the goal of treating or improving ADSL deficiency. A better effect in the treatment or improvement of ADSL deficiency is expected from the joint use of at least two of the described compounds.
Inventors:
PAN WUGUANG (CN)
ZHU WEI (CN)
ZHU WEI (CN)
Application Number:
PCT/CN2017/101066
Publication Date:
April 05, 2018
Filing Date:
September 08, 2017
Export Citation:
Assignee:
GENEHEAL BIOTECHNOLOGY CO LTD (CN)
International Classes:
A61P25/00; A61K31/397; A61K31/40; A61K31/4188; A61K31/435; C07D213/00; C07D403/00; C07D487/00; C07D513/00
Foreign References:
| US3462529A | 1969-08-19 |
Other References:
HARGIS, J.C. ET AL.: "Identification and Characterization of Noncovalent Interactions that Drive Binding and Specificity in DD -peptidases and beta-la-ctamases", JOURNAL OF CHEMICAL THEORY AND COMPUTATION, vol. 10, no. 2, 29 January 2014 (2014-01-29), pages 855 - 864, XP055515224
WEBB, M.R. ET AL.: "A Series of Related Nucleotide Analogues that Aids Optimization of Fluorescence Signals in Probing the Mechanism of P-Loop ATPases, Such as Actomyosin", BIOCHEMISTRY, vol. 43, no. 45, 21 October 2004 (2004-10-21), pages 14463 - 14471, XP055515219
SCOTT, A.I. ET AL.: "Reconstitution of Apo-porphobilinogen Deaminase: Structural Changes Induced by Cofactor Binding", FEBS LETTERS, vol. 242, no. 2, 30 January 1989 (1989-01-30), pages 319 - 324, XP025814091
WEBB, M.R. ET AL.: "A Series of Related Nucleotide Analogues that Aids Optimization of Fluorescence Signals in Probing the Mechanism of P-Loop ATPases, Such as Actomyosin", BIOCHEMISTRY, vol. 43, no. 45, 21 October 2004 (2004-10-21), pages 14463 - 14471, XP055515219
SCOTT, A.I. ET AL.: "Reconstitution of Apo-porphobilinogen Deaminase: Structural Changes Induced by Cofactor Binding", FEBS LETTERS, vol. 242, no. 2, 30 January 1989 (1989-01-30), pages 319 - 324, XP025814091
Attorney, Agent or Firm:
JIAQUAN IP LAW FIRM (CN)
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