Title:
COMPOUNDS THAT ABROGATE DNA-DAMAGE-INDUCED CELL CYCLE G2 CHECKPOINT AND/OR AUGMENT THE ANTI-CANCER ACTIVITY OF DNA-DAMAGING TREATMENTS
Document Type and Number:
WIPO Patent Application WO2003104181
Kind Code:
A3
Abstract:
The invention provides compositions and methods to inhibit the cell cycle G2 checkpoint, in particular the DNA-damage-induced G2 checkpoint, in mammalian cells including human cells. Specifically, the invention provides compositions and methods to sensitize cells to DNA-damaging agents by abrogating the cell cycle G2 checkpoint. Compounds of the invention are used to treat Proliferative disorders such as cancer. The invention provides compositions and methods for selectively sensitizing G1 checkpoint impaired cancer cells to DNA-damaging agents and treatments.
Inventors:
KAWABE TAKUMI (JP)
KOBAYASHI HIDETAKA (JP)
KOBAYASHI HIDETAKA (JP)
Application Number:
PCT/IB2003/003164
Publication Date:
July 29, 2004
Filing Date:
June 06, 2003
Export Citation:
Assignee:
CANBAS CO LTD (JP)
KAWABE TAKUMI (JP)
KOBAYASHI HIDETAKA (JP)
KAWABE TAKUMI (JP)
KOBAYASHI HIDETAKA (JP)
International Classes:
A61K31/222; A61K31/265; A61P35/00; C07C69/76; C07C69/773; C07C327/26; C07C327/36; C07D213/65; A61K31/44; G01N33/50; (IPC1-7): C07C69/773; C07C69/78; C07D213/65; C07C327/26; C07C327/36; A61P35/00; A61K31/235; G01N33/50
Domestic Patent References:
| WO1999048495A1 | 1999-09-30 | |||
| WO1997046228A1 | 1997-12-11 | |||
| WO1999047522A1 | 1999-09-23 | |||
| WO1999015157A2 | 1999-04-01 | |||
| WO2001021771A2 | 2001-03-29 |
Foreign References:
| US4394389A | 1983-07-19 | |||
| EP0409728A2 | 1991-01-23 | |||
| DE2049865A1 | 1972-04-13 | |||
| US6211164B1 | 2001-04-03 |
Other References:
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CHEMICAL ABSTRACTS, vol. 58, no. 4, 18 February 1963, Columbus, Ohio, US; abstract no. 3341g, S. D. JOLAD ET AL.: "Substituted benzophenones." page 3341; column 1; XP002266802
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOEDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002266804
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOEDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002266805
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOEDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002266806
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOEDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002266807
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOEDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002266808
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOEDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002266809
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOEDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002266810
CHEMICAL ABSTRACTS, vol. 92, no. 22, 2 June 1980, Columbus, Ohio, US; abstract no. 189424e, DEUTSCHER H. J. ET AL.: "Liquid-crystalline hydroquinone bis(trans-4-n-alkylcyclohexanecarboxylates)." page 559; column 2; XP002266803
ZOE A. STEWART AND JENNIFER A. PIENTENPOL: "G2 Checkpoint and Anticancer Therapy", EUREKA, 25 January 2001 (2001-01-25), pages 1 - 28, XP002280757, Retrieved from the Internet
ANTONIO M. SERAFIN ET AL.: "Chemosensitivity of prostatic tumour cell lines under conditions of G2 block abrogation", UROL RES, vol. 29, 2001, pages 221 - 227, XP002280758
PIERS EDWARD ET AL: "Improved Synthesis of Isogranulatimide, a G2 Checkpoint Inhibitor. Syntheses of Didemnimide C, Isodidemnimide A, Neodidemnimide A, 17-Methylgranulatimide, and Isogranulatimides A-C", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 65, 28 January 2000 (2000-01-28), pages 530 - 535, XP002175370, ISSN: 0022-3263
YULI WANG ET AL.: "Radiosensitization of p53 Mutant cells by PD0166285, a novel G2 checkpoint abrogator", CANCER RESEARCH., vol. 61, 15 November 2001 (2001-11-15), AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD., US, pages 8211 - 8217, XP002280759, ISSN: 0008-5472
CHEMICAL ABSTRACTS, vol. 58, no. 4, 18 February 1963, Columbus, Ohio, US; abstract no. 3341g, S. D. JOLAD ET AL.: "Substituted benzophenones." page 3341; column 1; XP002266802
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOEDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002266804
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOEDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002266805
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOEDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002266806
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOEDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002266807
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOEDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002266808
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOEDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002266809
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOEDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002266810
CHEMICAL ABSTRACTS, vol. 92, no. 22, 2 June 1980, Columbus, Ohio, US; abstract no. 189424e, DEUTSCHER H. J. ET AL.: "Liquid-crystalline hydroquinone bis(trans-4-n-alkylcyclohexanecarboxylates)." page 559; column 2; XP002266803
ZOE A. STEWART AND JENNIFER A. PIENTENPOL: "G2 Checkpoint and Anticancer Therapy", EUREKA, 25 January 2001 (2001-01-25), pages 1 - 28, XP002280757, Retrieved from the Internet
ANTONIO M. SERAFIN ET AL.: "Chemosensitivity of prostatic tumour cell lines under conditions of G2 block abrogation", UROL RES, vol. 29, 2001, pages 221 - 227, XP002280758
PIERS EDWARD ET AL: "Improved Synthesis of Isogranulatimide, a G2 Checkpoint Inhibitor. Syntheses of Didemnimide C, Isodidemnimide A, Neodidemnimide A, 17-Methylgranulatimide, and Isogranulatimides A-C", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 65, 28 January 2000 (2000-01-28), pages 530 - 535, XP002175370, ISSN: 0022-3263
YULI WANG ET AL.: "Radiosensitization of p53 Mutant cells by PD0166285, a novel G2 checkpoint abrogator", CANCER RESEARCH., vol. 61, 15 November 2001 (2001-11-15), AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD., US, pages 8211 - 8217, XP002280759, ISSN: 0008-5472
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