COMPOUNDS FOR TREATMENT OF INFLAMMATION, DIABETES AND RELATED DISORDERS

Title:

COMPOUNDS FOR TREATMENT OF INFLAMMATION, DIABETES AND RELATED DISORDERS

Document Type and Number:

WIPO Patent Application WO2004101752

Kind Code:

A3

Abstract:

Novel acyl urea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine-mediated inflammatory response in cultured cells, in ameliorating bone destruction in an animal model of arthritis and in lowering blood glucose levels in animal models of Type II diabetes mellitus. The compounds are disclosed as useful for a variety of treatments including the treatment of diabetes mellitus, insulin resistance, inflammation, inflammatory diseases, immunological diseases and cancer.

Inventors:

NEOGI PARTHA (US)
DEY DEBEDRANATH (US)
FULLER JOSEPH C (US)
CHEN LIANG (US)
LI TA-KAI (US)

Application Number:

PCT/US2004/014394

Publication Date:

February 16, 2006

Filing Date:

May 07, 2004

Export Citation:

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Assignee:

THERACOS INC (US)
NEOGI PARTHA (US)
DEY DEBEDRANATH (US)
FULLER JOSEPH C (US)
CHEN LIANG (US)
LI TA-KAI (US)

International Classes:

A61P3/10; C07C235/34; C07C271/64; C07C275/50; C07C281/06; C07C317/22; C07D213/56; C07D213/643; C07D213/75; C07D295/185; C07D213/64; C12N; (IPC1-7): A61K31/17; C07C303/00; C07C335/00

Foreign References:

US6646004B1

2003-11-11

Other References: