Title:
COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS
Document Type and Number:
WIPO Patent Application WO2003053915
Kind Code:
A3
Abstract:
This invention relates to compounds of the Formula (I):(Chemical formula should be inserted here as it appears on abstract in paper form)(I)or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, TNF-alpha or combinations thereof.
Inventors:
ZHU ZHAONING
MAZZOLA JR ROBERT
GUO ZHUYAN
LAVEY BRIAN J
SINNING LISA
KOZLOWSKI JOSEPH
MCKITTRICK BRIAN
SHIH NENG-YANG
MAZZOLA JR ROBERT
GUO ZHUYAN
LAVEY BRIAN J
SINNING LISA
KOZLOWSKI JOSEPH
MCKITTRICK BRIAN
SHIH NENG-YANG
Application Number:
PCT/US2002/040453
Publication Date:
September 18, 2003
Filing Date:
December 19, 2002
Export Citation:
Assignee:
SCHERING CORP (US)
International Classes:
A61K31/165; A61K31/167; A61K31/194; A61K31/216; A61K31/277; A61K31/36; A61K31/4164; A61K31/4192; A61K31/428; A61K31/435; C07D249/06; A61K31/44; A61K31/4406; A61K31/4409; A61K31/47; A61K31/4709; A61K31/495; A61K31/496; A61K31/5377; A61P1/00; A61P1/02; A61P3/10; A61P9/00; A61P11/00; A61P11/02; A61P13/12; A61P17/06; A61P19/00; A61P19/02; A61P25/00; A61P27/02; A61P27/06; A61P29/00; A61P31/04; A61P31/18; A61P33/06; A61P35/04; A61P37/06; A61P37/08; C07C61/39; C07C62/34; C07C69/757; C07C233/63; C07C235/40; C07C255/54; C07C259/08; C07C279/08; C07C311/21; C07C311/29; C07C317/22; C07C323/19; C07D213/30; C07D213/40; C07D213/73; C07D213/74; C07D215/14; C07D215/18; C07D215/233; C07D215/26; C07D215/38; C07D219/02; C07D221/16; C07D233/54; C07D233/58; C07D271/06; C07D277/24; C07D277/44; C07D277/64; C07D295/18; C07D311/58; C07D317/64; C07D401/04; C07D401/12; C07D413/12; C07D417/12; C07D215/22; (IPC1-7): C07C259/08; C07C69/743; C07D215/14; C07D277/44; C07D233/22; A61K31/16; A61K31/215; A61K31/415; A61K31/47; A61P19/02
Domestic Patent References:
| WO2000059874A1 | 2000-10-12 | |||
| WO1994027947A1 | 1994-12-08 |
Foreign References:
| AU534404B2 | 1984-01-26 | |||
| GB2200628A | 1988-08-10 | |||
| US4435419A | 1984-03-06 | |||
| EP1029851A1 | 2000-08-23 | |||
| EP0952148A1 | 1999-10-27 |
Other References:
PATENT ABSTRACTS OF JAPAN vol. 018, no. 032 (C - 1154) 18 January 1994 (1994-01-18)
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002244521, Database accession no. 3152815
HANESSIAN S ET AL: "Synthesis of conformationally constrained potential inhibitors of mammalian metalloproteinases", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 7, no. 24, 16 December 1997 (1997-12-16), pages 3119 - 3124, XP004136596, ISSN: 0960-894X
GHOSE, A K ET AL: "Determination of pharmacophoric geomettry for collagenase inhibitors using a novel computational method and its verification using molecular dynamics, NMR and X-ray crystallography", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 117, no. 16, 1995, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC., US, pages 4671 - 4682, XP002244520, ISSN: 0002-7863
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002244521, Database accession no. 3152815
HANESSIAN S ET AL: "Synthesis of conformationally constrained potential inhibitors of mammalian metalloproteinases", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 7, no. 24, 16 December 1997 (1997-12-16), pages 3119 - 3124, XP004136596, ISSN: 0960-894X
GHOSE, A K ET AL: "Determination of pharmacophoric geomettry for collagenase inhibitors using a novel computational method and its verification using molecular dynamics, NMR and X-ray crystallography", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 117, no. 16, 1995, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC., US, pages 4671 - 4682, XP002244520, ISSN: 0002-7863
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