Title:
COMPOUNDS FOR USE IN BOOSTING COAGULATION
Document Type and Number:
WIPO Patent Application WO/2013/028070
Kind Code:
A3
Abstract:
The present invention relates to inhibitors of antithrombin III and the medical use thereof in treating or preventing bleeding. The inhibitors are preferably used in subjects suffering from an acquired or genetic bleeding disorder, such as haemophilia, or in a subjects having a clinical condition characterised by excessive bleeding, such as surgery, trauma and internal bleeding. The inhibitor of antithrombin III can e.g. a peptide, an aptamer or an antibody or antibody fragment that specifically binds to and inhibits antithrombin III.
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Inventors:
HACK CORNELIS ERIK (NL)
YILDIZ CAFER (NL)
YILDIZ CAFER (NL)
Application Number:
PCT/NL2012/050581
Publication Date:
April 18, 2013
Filing Date:
August 24, 2012
Export Citation:
Assignee:
UMC UTRECHT HOLDING BV (NL)
HACK CORNELIS ERIK (NL)
YILDIZ CAFER (NL)
HACK CORNELIS ERIK (NL)
YILDIZ CAFER (NL)
International Classes:
A61K38/57; A61P7/04; C07K16/36; G01N33/86
Domestic Patent References:
| WO2009013251A1 | 2009-01-29 |
Other References:
BJORK I ET AL: "CONVERSION OF ANTITHROMBIN FROM AN INHIBITOR OF THROMBIN TO A SUBSTRATE WITH REDUCED HEPARIN AFFINITY AND ENHANCED CONFORMATIONAL STABILITY BY BINDING OF A TETRADECAPEPTIDE CORRESPONDING TO THE P-1 TO P-14 REGION OF THE PUTATIVE REACTIVE BOND LOOP OF THE INHIBITOR", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 267, no. 3, 1992, pages 1976 - 1982, XP055054309, ISSN: 0021-9258
MUSZBEK LASZLO ET AL: "Antithrombin deficiency and its laboratory diagnosis", CLINICAL CHEMISTRY AND LABORATORY MEDICINE, vol. 48, no. Suppl. 1, December 2010 (2010-12-01), pages S67 - S78, XP009167217, ISSN: 1434-6621
KUMMER J A ET AL: "Production, characterization, and use of serpin antibodies", METHODS : A COMPANION TO METHODS IN ENZYMOLOGY, ACADEMIC PRESS INC., NEW YORK, NY, US, vol. 32, no. 2, 1 February 2004 (2004-02-01), pages 141 - 149, XP004481665, ISSN: 1046-2023, DOI: 10.1016/S1046-2023(03)00205-6
MAYER STEPHAN A ET AL: "Recombinant activated factor VII for acute intracerebral hemorrhage", NEW ENGLAND JOURNAL OF MEDICINE, THE, MASSACHUSETTS MEDICAL SOCIETY, WALTHAM, MA, US, vol. 352, no. 8, 24 February 2005 (2005-02-24), pages 777 - 785, XP002449328, ISSN: 0028-4793, DOI: 10.1056/NEJMOA042991
MUSZBEK LASZLO ET AL: "Antithrombin deficiency and its laboratory diagnosis", CLINICAL CHEMISTRY AND LABORATORY MEDICINE, vol. 48, no. Suppl. 1, December 2010 (2010-12-01), pages S67 - S78, XP009167217, ISSN: 1434-6621
KUMMER J A ET AL: "Production, characterization, and use of serpin antibodies", METHODS : A COMPANION TO METHODS IN ENZYMOLOGY, ACADEMIC PRESS INC., NEW YORK, NY, US, vol. 32, no. 2, 1 February 2004 (2004-02-01), pages 141 - 149, XP004481665, ISSN: 1046-2023, DOI: 10.1016/S1046-2023(03)00205-6
MAYER STEPHAN A ET AL: "Recombinant activated factor VII for acute intracerebral hemorrhage", NEW ENGLAND JOURNAL OF MEDICINE, THE, MASSACHUSETTS MEDICAL SOCIETY, WALTHAM, MA, US, vol. 352, no. 8, 24 February 2005 (2005-02-24), pages 777 - 785, XP002449328, ISSN: 0028-4793, DOI: 10.1056/NEJMOA042991
Attorney, Agent or Firm:
PALLARD, Caroline (JS The Hague, NL)
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