COMPRESSED SOLID DOSAGE FORM MANUFACTURING PROCESS WELL-SUITED FOR USE WITH DRUGS OF LOW AQUEOUS SOLUBILITY AND COMPRESSED SOLID DOSAGE FORMS MADE THEREBY

Title:

COMPRESSED SOLID DOSAGE FORM MANUFACTURING PROCESS WELL-SUITED FOR USE WITH DRUGS OF LOW AQUEOUS SOLUBILITY AND COMPRESSED SOLID DOSAGE FORMS MADE THEREBY

Document Type and Number:

WIPO Patent Application WO2006052254

Kind Code:

A3

Abstract:

A pharmaceutical formulation of compounds with low aqueous solubility and method of manufacture thereof. The formulation may include a pharmacologically active compound having low aqueous solubility and starch in the amount of greater than about (25) weight percent. A manufacturing method may include blending the active compound and starch, compressing the blend into a solid, comminuting the solid into granules, wetting the granules, drying the granules, and tabletting the dried granules to make a solid pharmaceutical formulation.

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Inventors:

ZALIT ILAN (IL)
LESKA FANNY (IL)
KADOSH MALI (IL)
MARCO DORIT (IL)
MESSER-TRIGER YONIT (IL)

Application Number:

PCT/US2004/037462

Publication Date:

August 17, 2006

Filing Date:

November 10, 2004

Export Citation:

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Assignee:

TEVA PHARMA (US)
TEVA PHARMA (US)
ZALIT ILAN (IL)
LESKA FANNY (IL)
KADOSH MALI (IL)
MARCO DORIT (IL)
MESSER-TRIGER YONIT (IL)

International Classes:

A61K9/20

Domestic Patent References:

WO2004066910A2	2004-08-12
WO2002003987A2	2002-01-17

Foreign References:

EP1438957A1

2004-07-21

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