Title:
COMPUTATIONAL ANALYSIS OF MASS SPECTROSCOPIC LIPID DATA
Document Type and Number:
WIPO Patent Application WO2005085838
Kind Code:
A3
Abstract:
The present invention provides methods for developing a lipid profile from cells using a computational statistical analysis of a lipid data array derived from mass spectroscopy. The methods have particular utility in diagnosing disease, screening drugs, and identifying new lipids and lipid-linked pathways.
Inventors:
BROWN H ALEX (US)
FORRESTER JEFFREY (US)
FORRESTER JEFFREY (US)
Application Number:
PCT/US2005/006843
Publication Date:
January 19, 2006
Filing Date:
March 02, 2005
Export Citation:
Assignee:
UNIV VANDERBILT (US)
BROWN H ALEX (US)
FORRESTER JEFFREY (US)
BROWN H ALEX (US)
FORRESTER JEFFREY (US)
International Classes:
G01N33/00; (IPC1-7): G06F19/00
Domestic Patent References:
| WO2002004957A2 | 2002-01-17 |
Other References:
MILNE SB, FORRESTER JS, IVANOVA PT, ARMSTRONG MD, BROWN HA: "Multiplexed Lipid Arrays of Anti-Immunoglobulin M-Induced Changes in the Glycerophospholipid Composition of WEHI-231 Cells", ALLIANCE FOR CELLULAR SIGNALLING RESEARCH REPORTS, vol. 1, no. 11, 24 October 2003 (2003-10-24), pages 1 - 11, XP002354051, Retrieved from the Internet [retrieved on 20051115]
HAN X, GROSS RW: "Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: a bridge to lipidomics", JOURNAL OF LIPID RESEARCH, vol. 44, 2003, pages 1071 - 1079, XP002354052, Retrieved from the Internet [retrieved on 20051115]
HAN X, GROSS RW: "Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: a bridge to lipidomics", JOURNAL OF LIPID RESEARCH, vol. 44, 2003, pages 1071 - 1079, XP002354052, Retrieved from the Internet
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