Title:
CONCENTRATE GROWTH FACTOR SLOW RELEASE FREEZE-DRIED MEMBRANE AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2020/113933
Kind Code:
A1
Abstract:
A concentrate growth factor slow release freeze-dried membrane and a preparation method therefor. The preparation method comprises the following steps: providing concentrate growth factors; dispersing the concentrate growth factors in an aqueous solution of sodium alginate to obtain a mixed solution; dropwise adding the mixed solution to an aqueous solution containing divalent metal cations while stirring so as to enable the sodium alginate to clad the concentrate growth factors and obtain composite microspheres of the concentrate growth factors and the sodium alginate; and dispersing the composite microspheres in an aqueous solution of chitosan, and performing freeze drying so as to obtain the concentrate growth factor slow release freeze-dried membrane. The concentrate growth factor slow release freeze-dried membrane prepared by the method has the advantages that the release rate of the concentrate growth factors is controllable, the mechanical property is good, and the membrane can be stored for a long term.
Inventors:
WANG LIPING (CN)
XIAO YIN (CN)
WAN MIANJIA (CN)
LI ZHENGMAO (CN)
DU ZHIBIN (CN)
SU YUCHENG (CN)
GE LINHU (CN)
XIAO YIN (CN)
WAN MIANJIA (CN)
LI ZHENGMAO (CN)
DU ZHIBIN (CN)
SU YUCHENG (CN)
GE LINHU (CN)
Application Number:
PCT/CN2019/091155
Publication Date:
June 11, 2020
Filing Date:
June 13, 2019
Export Citation:
Assignee:
WANG LIPING (CN)
International Classes:
A61K9/70; A61K38/18; A61K47/36; A61P19/08
Foreign References:
| CN109528692A | 2019-03-29 | |||
| CN103467755A | 2013-12-25 | |||
| CN105999368A | 2016-10-12 | |||
| CN106334184A | 2017-01-18 | |||
| CN102258481A | 2011-11-30 |
Other References:
SORAN, Z. ET AL.: "Chitosan Scaffolds with BMP-6 Loaded Alginate Microspheres for Periodontal Tissue Engineering", JOURNAL OF MICROENCAPSULATION, vol. 29, no. 8, 31 December 2012 (2012-12-31), XP055712056, DOI: 20190814091221
RIVA, B. ET AL.: "VEGF-Controlled Release within a Bone Defect from Alginate/Chitosan/PLA-H Scaffolds", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 73, 12 May 2009 (2009-05-12), XP026467629, DOI: 20190814091341X
RIVA, B. ET AL.: "VEGF-Controlled Release within a Bone Defect from Alginate/Chitosan/PLA-H Scaffolds", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 73, 12 May 2009 (2009-05-12), XP026467629, DOI: 20190814091341X
Attorney, Agent or Firm:
ADVANCE CHINA IP LAW OFFICE (CN)
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