Title:
CONDENSED 7-MEMBERED RING COMPOUNDS AND PROCESS FOR THEIR PREPARATION
Document Type and Number:
WIPO Patent Application WO/1986/000618
Kind Code:
A1
Abstract:
Novel condensed 7-membered ring compounds represented by formula (I), (wherein R1 and R2 each represents hydrogen, halogen, trifluoromethyl, lower alkyl or lower alkoxy or, when taken together, they represent tri- or tetramethylene, R3 and R5 each represents hydrogen, lower alkyl or arakyl, R4 represents hydrogen or lower alkyl, R6 represents a condensed or non-condensed hetero-alicyclic group containing at least one N, O or S as a ring atom, A represents an alkylene chain, and n represents 1 or 2) and salts thereof. These compounds and their salts are effective in inhibiting angiotensin-converting enzyme, and are useful for diagnosis, prophylaxis, and treatment of circulatory system diseases, e.g., hypertension, heart disease or apoplexy.
Inventors:
SUGIHARA HIROSADA (JP)
NISHIKAWA KOHEI (JP)
ITO KATSUMI (JP)
NISHIKAWA KOHEI (JP)
ITO KATSUMI (JP)
Application Number:
PCT/JP1984/000363
Publication Date:
January 30, 1986
Filing Date:
July 13, 1984
Export Citation:
Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD (JP)
International Classes:
C07D209/48; C07D281/10; C07D417/04; C07K5/02; A61K38/00; (IPC1-7): C07D281/10; C07D417/12
Foreign References:
| JPS58116477A | 1983-07-11 |
Other References:
Chemical Abstracts, Vol. 94, No. 19, (1981-5-11) (Columbus, Ohio, U.S.A.) Levai, A:, "Oxazepines and thiazepines. Part 10: Sythesis of carboxylic acid derivatives of 2,3-dihydro-2-phenyl-1,5-benzothiazepin-4-(5H)-ones.", Page 657, 2nd step, Abstract No. 94: 156884t; & Pharmazie, 35680
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